Evidence map›Paper›PMID 33096046›Full record

SynthesisThe lancet. Psychiatry2020

A large-scale genome-wide association study meta-analysis of cannabis use disorder.

Emma C Johnson, Ditte Demontis, Thorgeir E Thorgeirsson, Raymond K Walters, Renato Polimanti, Alexander S Hatoum, Sandra Sanchez-Roige, Sarah E Paul, Frank R Wendt, Toni-Kim Clarke and 93 more

Erratum issuedAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The lancet. Psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 217 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
217citing papers in PubMed, 18 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

217 citing papers in PubMed, 18 syntheses or guidelines pooled it.

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157 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

103 authors.

Emma C JohnsonDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA. Electronic address: emma.c.johnson@wustl.edu.
Ditte DemontisDepartment of Biomedicine-Human Genetics and Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Center for Genomics and Personalized Medicine, Aarhus, Denmark.
Thorgeir E ThorgeirssonCNS Department, Reykjavik, Iceland.
Raymond K WaltersAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Renato PolimantiDivision of Human Genetics, Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA.
Alexander S HatoumDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Sandra Sanchez-RoigeDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA; Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Sarah E PaulDepartment of Psychological and Brain Sciences, Washington University in Saint Louis, St. Louis, MO, USA.
Frank R WendtDivision of Human Genetics, Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA.
Toni-Kim ClarkeDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
Dongbing LaiDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Gunnar W ReginssonCNS Department, Reykjavik, Iceland.
Hang ZhouDivision of Human Genetics, Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA.
June HeDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
David A A BarangerDepartment of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Daniel F GudbjartssonStatistics Department, Reykjavik, Iceland; School of Engineering and Natural Sciences, Iceland University, Reykjavik, Iceland.
Robbee WedowAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Daniel E AdkinsDepartment of Psychiatry, University of Utah, Salt Lake City, UT, USA; Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA; College Behavioral and Emotional Health Institute, Virginia Commonwealth University, Richmond, VA, USA.
Amy E AdkinsDepartment of Psychiatry, University of Utah, Salt Lake City, UT, USA; Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA; College Behavioral and Emotional Health Institute, Virginia Commonwealth University, Richmond, VA, USA.
Jeffry AlexanderVirginia Commonwealth University Alcohol Research Center, Virginia Commonwealth University, Richmond, VA, USA.
Silviu-Alin BacanuVirginia Commonwealth University Alcohol Research Center, Virginia Commonwealth University, Richmond, VA, USA.
Tim B BigdeliDepartment of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Joseph BodenDepartment of Psychological Medicine, University of Otago, Christchurch, New Zealand.
Sandra A BrownDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA; Department of Psychology and Office of Research Affairs, University of California San Diego, La Jolla, CA, USA.
Kathleen K BucholzDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Jonas Bybjerg-GrauholmThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Department for Congenital Disorders, Center for Neonatal Screening, Statens Serum Institut, Copenhagen, Denmark.
Robin P CorleyInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Louisa DegenhardtNational Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, Australia.
Danielle M DickDepartment of Psychology, Virginia Commonwealth University, Richmond, VA, USA; Department of Human & Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Benjamin W DomingueStanford University Graduate School of Education, Stanford University, Stanford, CA, USA.
Louis FoxDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Alison M GoateDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Scott D GordonQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Laura M HackDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Dana B HancockGenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, Durham, NC, USA.
Sarah M HartzDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Ian B HickieBrain and Mind Centre, University of Sydney, Sydney, Australia.
David M HougaardThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Department for Congenital Disorders, Center for Neonatal Screening, Statens Serum Institut, Copenhagen, Denmark.
Kenneth KrauterDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA; University of Colorado Boulder, Boulder, CO, USA.
Penelope A LindQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Jeanette N McClintickDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Matthew B McQueenDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Jacquelyn L MeyersDepartment of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA; Henri Begleiter Neurodynamics Laboratory, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Grant W MontgomeryInstitute for Molecular Bioscience, University of Queensland, QLD, Australia.
Ole MorsThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Psychosis Research Unit, Aarhus University Hospital, Aarhus, Denmark.
Preben B MortensenNational Centre for Register-Based Research, Aarhus University, Aarhus, Denmark; Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
Merete NordentoftThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark.
John F PearsonBiostatistics and Computational Biology Unit, University of Otago, Christchurch, New Zealand; Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
Roseann E PetersonDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Maureen D ReynoldsSchool of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.
John P RiceDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Valgerdur RunarsdottirSAA-National Center of Addiction Medicine, Vogur Hospital, Reykjavik, Iceland.
Nancy L SacconeDepartment of Genetics, Washington University School of Medicine, St Louis, MO, USA; Division of Biostatistics, Washington University School of Medicine, St Louis, MO, USA.
Richard ShervaDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
Judy L SilbergDepartment of Human & Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA; Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Ralph E TarterSchool of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.
Thorarinn TyrfingssonSAA-National Center of Addiction Medicine, Vogur Hospital, Reykjavik, Iceland.
Tamara L WallDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Bradley T WebbVirginia Commonwealth University Alcohol Research Center, Virginia Commonwealth University, Richmond, VA, USA.
Thomas WergeThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Medicine, and Center for GeoGenetics, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark.
Leah WetherillDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Margaret J WrightQueensland Brain Institute, University of Queensland, QLD, Australia.
Stephanie ZellersDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Mark J AdamsDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
Laura J BierutDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Jason D BoardmanInstitute of Behavioral Science and Department of Sociology, University of Colorado Boulder, Boulder, CO, USA.
William E CopelandDepartment of Psychiatry, University of Vermont Medical Center, Burlington, VT, USA.
Lindsay A FarrerDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
Tatiana M ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Nathan A GillespieDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Richard A GruczaDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Kathleen Mullan HarrisDepartment of Sociology, and The Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Andrew C HeathDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Victor HesselbrockDepartment of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, USA.
John K HewittInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Christian J HopferDepartment of Psychiatry, University of Colorado Denver, Aurora, CO, USA.
John HorwoodDepartment of Psychological Medicine, University of Otago, Christchurch, New Zealand.
William G IaconoDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Eric O JohnsonGenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, Durham, NC, USA.
Kenneth S KendlerDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Martin A KennedyDepartment of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
Henry R KranzlerCenter for Studies of Addiction, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; VISN 4 MIRECC, Crescenz VAMC, Philadelphia, PA, USA.
Pamela A F MaddenDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Hermine H MaesDepartment of Human & Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA; Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Brion S MaherDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Matthew McGueDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Andrew M McIntoshDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
Sarah E MedlandQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Elliot C NelsonDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Bernice PorjeszDepartment of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA; Henri Begleiter Neurodynamics Laboratory, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Brien P RileyVirginia Commonwealth University Alcohol Research Center, Virginia Commonwealth University, Richmond, VA, USA.
Michael C StallingsInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Michael M VanyukovSchool of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.
Scott VriezeDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Psychiatric Genomics Consortium Substance Use Disorders Workgroup
Lea K DavisDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Psychiatry and Behavioral Sciences, and Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Ryan BogdanDepartment of Psychological and Brain Sciences, Washington University in Saint Louis, St. Louis, MO, USA.
Joel GelernterDivision of Human Genetics, Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Department of Genetics, and Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA; Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA.
Howard J EdenbergDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Kari StefanssondeCODE Genetics/Amgen, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Anders D BørglumDepartment of Biomedicine-Human Genetics and Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Center for Genomics and Personalized Medicine, Aarhus, Denmark.
Arpana AgrawalDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.

Funding

Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JAY Arnold TISCHFIELD · 1989 to 2026
$162.7M
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Wave IV Data CollectionP01HD031921 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HARRIS, KATHLEEN MULLAN · 1994 to 2020
$86.1M
ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$52.0M
ABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Adolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5M
ABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7M
Prospective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2M
ABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7M
Medical Research Council MC_PC_17209Medical Research Council MC_UU_00007/10Medical Research Council MR/S035818/1NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR001863NCATS NIH HHS UL1 TR002243NCI NIH HHS P01 CA089392NCRR NIH HHS S10 RR025141NCRR NIH HHS UL1 RR024975NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS N01 HG065403NHGRI NIH HHS R01 HG008983NHGRI NIH HHS U01 HG004422NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01 HG004798NHGRI NIH HHS U01 HG006378NHLBI NIH HHS U19 HL065962NIAAA NIH HHS F32 AA027435NIAAA NIH HHS K02 AA018755NIAAA NIH HHS K05 AA017688NIAAA NIH HHS P20 AA017828NIAAA NIH HHS P50 AA011998NIAAA NIH HHS P50 AA022537NIAAA NIH HHS R01 AA007535NIAAA NIH HHS R01 AA007728NIAAA NIH HHS R01 AA009367NIAAA NIH HHS R01 AA011330NIAAA NIH HHS R01 AA011408NIAAA NIH HHS R01 AA013320NIAAA NIH HHS R01 AA013321NIAAA NIH HHS R01 AA014041NIAAA NIH HHS R01 AA017444NIAAA NIH HHS R01 AA017535NIAAA NIH HHS R21 AA027827NIAAA NIH HHS R37 AA007728NIAAA NIH HHS R37 AA009367NIAAA NIH HHS U10 AA008401NIA NIH HHS R01 AG061162NIBIB NIH HHS U54 EB020403NICHD NIH HHS P01 HD031921NICHD NIH HHS P2C HD066613NICHD NIH HHS R01 HD050735NICHD NIH HHS R01 HD060726NICHD NIH HHS R01 HD073342NICHD NIH HHS R01 HD074711NICHD NIH HHS R01 HD093651NICHD NIH HHS R03 HD097630NIDA NIH HHS K02 DA032573NIDA NIH HHS K08 DA019951NIDA NIH HHS K24 DA032555NIDA NIH HHS P30 DA023026NIDA NIH HHS P50 DA005605NIDA NIH HHS P60 DA011015NIDA NIH HHS R00 DA023549NIDA NIH HHS R01 DA005147NIDA NIH HHS R01 DA011301NIDA NIH HHS R01 DA012690NIDA NIH HHS R01 DA012845NIDA NIH HHS R01 DA012849NIDA NIH HHS R01 DA012854NIDA NIH HHS R01 DA013240NIDA NIH HHS R01 DA013423NIDA NIH HHS R01 DA016977NIDA NIH HHS R01 DA017305NIDA NIH HHS R01 DA018432NIDA NIH HHS R01 DA018673NIDA NIH HHS R01 DA019157NIDA NIH HHS R01 DA019963NIDA NIH HHS R01 DA021905NIDA NIH HHS R01 DA021913NIDA NIH HHS R01 DA024413NIDA NIH HHS R01 DA024417NIDA NIH HHS R01 DA025109NIDA NIH HHS R01 DA026911NIDA NIH HHS R01 DA034076NIDA NIH HHS R01 DA035804NIDA NIH HHS R01 DA036216NIDA NIH HHS R01 DA037904NIDA NIH HHS R01 DA042755NIDA NIH HHS R01 DA044283NIDA NIH HHS R21 DA038504NIDA NIH HHS R21 DA046791NIDA NIH HHS R21 DA047527NIDA NIH HHS R37 DA005147NIDA NIH HHS R56 DA012854NIDA NIH HHS RC2 DA028909NIDA NIH HHS T32 DA007261NIDA NIH HHS U01 DA024413NIDA NIH HHS U01 DA024417NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U01 DA051038NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147NIDCD NIH HHS R21 DC018098NIGMS NIH HHS P50 GM115305NIGMS NIH HHS RC2 GM092618NIH HHS S10 OD025092NIMH NIH HHS F32 MH122058NIMH NIH HHS K01 MH093731NIMH NIH HHS K01 MH113848NIMH NIH HHS K23 MH080230NIMH NIH HHS R01 MH048085NIMH NIH HHS R01 MH063671NIMH NIH HHS R01 MH063970NIMH NIH HHS R01 MH066140NIMH NIH HHS R01 MH068521NIMH NIH HHS R01 MH077874NIMH NIH HHS R01 MH083094NIMH NIH HHS R01 MH117559NIMH NIH HHS R01 MH118233NIMH NIH HHS R01 MH123619NIMH NIH HHS R56 MH120736NIMH NIH HHS T32 MH018951NIMH NIH HHS U01 MH109514NIMH NIH HHS U01 MH109532NINDS NIH HHS R01 NS032830Wellcome Trust
6 · The paper itself

Abstract

backgroundVariation in liability to cannabis use disorder has a strong genetic component (estimated twin and family heritability about 50-70%) and is associated with negative outcomes, including increased risk of psychopathology. The aim of the study was to conduct a large genome-wide association study (GWAS) to identify novel genetic variants associated with cannabis use disorder.

methodsTo conduct this GWAS meta-analysis of cannabis use disorder and identify associations with genetic loci, we used samples from the Psychiatric Genomics Consortium Substance Use Disorders working group, iPSYCH, and deCODE (20 916 case samples, 363 116 control samples in total), contrasting cannabis use disorder cases with controls. To examine the genetic overlap between cannabis use disorder and 22 traits of interest (chosen because of previously published phenotypic correlations [eg, psychiatric disorders] or hypothesised associations [eg, chronotype] with cannabis use disorder), we used linkage disequilibrium score regression to calculate genetic correlations.

findingsWe identified two genome-wide significant loci: a novel chromosome 7 locus (FOXP2, lead single-nucleotide polymorphism [SNP] rs7783012; odds ratio [OR] 1·11, 95% CI 1·07-1·15, p=1·84 × 10

interpretationThese findings support the theory that cannabis use disorder has shared genetic liability with other psychopathology, and there is a distinction between genetic liability to cannabis use and cannabis use disorder.

fundingNational Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; National Institute on Drug Abuse; Center for Genomics and Personalized Medicine and the Centre for Integrative Sequencing; The European Commission, Horizon 2020; National Institute of Child Health and Human Development; Health Research Council of New Zealand; National Institute on Aging; Wellcome Trust Case Control Consortium; UK Research and Innovation Medical Research Council (UKRI MRC); The Brain & Behavior Research Foundation; National Institute on Deafness and Other Communication Disorders; Substance Abuse and Mental Health Services Administration (SAMHSA); National Institute of Biomedical Imaging and Bioengineering; National Health and Medical Research Council (NHMRC) Australia; Tobacco-Related Disease Research Program of the University of California; Families for Borderline Personality Disorder Research (Beth and Rob Elliott) 2018 NARSAD Young Investigator Grant; The National Child Health Research Foundation (Cure Kids); The Canterbury Medical Research Foundation; The New Zealand Lottery Grants Board; The University of Otago; The Carney Centre for Pharmacogenomics; The James Hume Bequest Fund; National Institutes of Health: Genes, Environment and Health Initiative; National Institutes of Health; National Cancer Institute; The William T Grant Foundation; Australian Research Council; The Virginia Tobacco Settlement Foundation; The VISN 1 and VISN 4 Mental Illness Research, Education, and Clinical Centers of the US Department of Veterans Affairs; The 5th Framework Programme (FP-5) GenomEUtwin Project; The Lundbeck Foundation; NIH-funded Shared Instrumentation Grant S10RR025141; Clinical Translational Sciences Award grants; National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; National Institute of General Medical Sciences.

Indexed as

Genome-Wide Association StudyHumansMarijuana AbusePolymorphism, Single NucleotideRisk

Identifiers

PMID33096046
PMCPMC7674631

What Socratic holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.