Evidence map›Paper›PMID 33096622›Full record

ReviewPathogens (Basel, Switzerland)2020

Control of Cytokines in Latent Cytomegalovirus Infection.

Pearley Chinta, Erica C Garcia, Kiran Hina Tajuddin, Naomi Akhidenor, Allyson Davis, Lionel Faure, Juliet V Spencer

Open access · goldAbstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Cytomegalovirus (CMV) Infection and Latency.Pathogens (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Pearley ChintaDepartment of Biology, Texas Woman's University, P.O. Box 425799, 1000 Old Main Circle, Denton, TX 76204, USA.
Erica C GarciaDepartment of Biology, Texas Woman's University, P.O. Box 425799, 1000 Old Main Circle, Denton, TX 76204, USA.
Kiran Hina TajuddinDepartment of Biology, Texas Woman's University, P.O. Box 425799, 1000 Old Main Circle, Denton, TX 76204, USA.
Naomi AkhidenorDepartment of Biology, Texas Woman's University, P.O. Box 425799, 1000 Old Main Circle, Denton, TX 76204, USA.
Allyson DavisDepartment of Biology, Texas Woman's University, P.O. Box 425799, 1000 Old Main Circle, Denton, TX 76204, USA.
Lionel FaureDepartment of Biology, Texas Woman's University, P.O. Box 425799, 1000 Old Main Circle, Denton, TX 76204, USA.
Juliet V SpencerDepartment of Biology, Texas Woman's University, P.O. Box 425799, 1000 Old Main Circle, Denton, TX 76204, USA.
Texas Woman's University · US

Funding

Chancellor's Research Fellows Program 2020-2021Research Enhancement Program 2019-2021TWU Biology Faculty Development Funds 2020-2021
6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) has evolved a number of mechanisms for long-term co-existence within its host. HCMV infects a wide range of cell types, including fibroblasts, epithelial cells, monocytes, macrophages, dendritic cells, and myeloid progenitor cells. Lytic infection, with the production of infectious progeny virions, occurs in differentiated cell types, while undifferentiated myeloid precursor cells are the primary site of latent infection. The outcome of HCMV infection depends partly on the cell type and differentiation state but is also influenced by the composition of the immune environment. In this review, we discuss the role of early interactions between HCMV and the host immune system, particularly cytokine and chemokine networks, that facilitate the establishment of lifelong latent infection. A better understanding of these cytokine signaling pathways could lead to novel therapeutic targets that might prevent latency or eradicate latently infected cells.

Indexed as

chemokinescmvIL-10cytokinescytomegalovirusinterferonsISGslatency

Identifiers

PMID33096622
PMCPMC7589642
OpenAlexW3094099479

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.