Evidence map›Paper›PMID 33096707›Full record

ArticleMolecules (Basel, Switzerland)2020

Semisynthetic Cardenolides Acting as Antiviral Inhibitors of Influenza A Virus Replication by Preventing Polymerase Complex Formation.

Laurita Boff, André Schreiber, Aline da Rocha Matos, Juliana Del Sarto, Linda Brunotte, Jennifer Munkert, Flaviano Melo Ottoni, Gabriela Silva Ramos, Wolfgang Kreis, Fernão Castro Braga and 4 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Laurita BoffInstitute of Virology (IVM), Centre for Molecular Biology of Inflammation (ZMBE), Westfaelische Wilhelms University (WWU), 48149 Münster, Germany.
André SchreiberInstitute of Virology (IVM), Centre for Molecular Biology of Inflammation (ZMBE), Westfaelische Wilhelms University (WWU), 48149 Münster, Germany.
Aline da Rocha MatosInstitute of Virology (IVM), Centre for Molecular Biology of Inflammation (ZMBE), Westfaelische Wilhelms University (WWU), 48149 Münster, Germany.
Juliana Del SartoInstitute of Virology (IVM), Centre for Molecular Biology of Inflammation (ZMBE), Westfaelische Wilhelms University (WWU), 48149 Münster, Germany.
Linda BrunotteInstitute of Virology (IVM), Centre for Molecular Biology of Inflammation (ZMBE), Westfaelische Wilhelms University (WWU), 48149 Münster, Germany.
Jennifer MunkertPharmaceutical Biology, Department of Biology, Friedrich-Alexander-University, 91054 Erlangen-Nuremberg, Germany.
Flaviano Melo OttoniDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil.ORCID 0000-0003-4307-4336
Gabriela Silva RamosDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil.ORCID 0000-0003-0085-9571
Wolfgang KreisPharmaceutical Biology, Department of Biology, Friedrich-Alexander-University, 91054 Erlangen-Nuremberg, Germany.ORCID 0000-0002-4239-4349
Fernão Castro BragaDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil.ORCID 0000-0001-9468-376X
Ricardo José AlvesDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil.
Rodrigo Maia de PáduaDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil.
Cláudia Maria Oliveira SimõesLaboratory of Applied Virology, Department of Pharmaceutical Sciences, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina 88040-900, Brazil.
Stephan LudwigInstitute of Virology (IVM), Centre for Molecular Biology of Inflammation (ZMBE), Westfaelische Wilhelms University (WWU), 48149 Münster, Germany.ORCID 0000-0003-4490-3052
Universidade Federal de Minas Gerais · BRInstitute of Molecular Biology · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversidade Federal de Santa Catarina · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPq grant number 200574/2018-3Conselho Nacional de Desenvolvimento Científico e Tecnológico grant number 305878/2016-6Deutsche Forschungsgemeinschaft grants SFB1009B02, LU477/23-1, BR 5189/1-1, KFO324FP7 People: Marie-Curie Actions FP7 IRSES, grant 295251, WK
6 · The paper itself

Abstract

Influenza virus infections represent a major public health issue by causing annual epidemics and occasional pandemics that affect thousands of people worldwide. Vaccination is the main prophylaxis to prevent these epidemics/pandemics, although the effectiveness of licensed vaccines is rather limited due to the constant mutations of influenza virus antigenic characteristics. The available anti-influenza drugs are still restricted and there is an increasing viral resistance to these compounds, thus highlighting the need for research and development of new antiviral drugs. In this work, two semisynthetic derivatives of digitoxigenin, namely

Indexed as

Antiviral AgentsCardenolidesHumansInfluenza A virusInfluenza, HumanMolecular ConformationRNA-Dependent RNA PolymeraseVirus ReplicationAntiviral AgentsCardenolidesRNA-Dependent RNA Polymeraseanti-influenzamechanism of actionpolymerase activity inhibitionsemisynthetic cardenolides

Identifiers

PMID33096707
PMCPMC7587960
OpenAlexW3094565721

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.