ArticleProceedings of the National Academy of Sciences of the United States of America2020
HLA tapasin independence: broader peptide repertoire and HIV control.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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55citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 82 citations in OpenAlex.
- Safety and antiviral effect of a triple combination of HIV-1 broadly neutralizing antibodies: a phase 1/2a trial.Nature medicine · 2024Trial
- Prediction of differential Gag versus Env responses to a mosaic HIV-1 vaccine regimen by HLA class I alleles.Journal of virology · 2024Trial
- Reconstitution of glycan-driven MHC-I recycling reveals calreticulin as mediator between TAPBPR and tapasin.The EMBO journal · 2026Article
- Quantitative nanoscale imaging shows peptide-MHC I complexes are monomeric and spatially regulated in human dendritic cells.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Engineering high-fidelity tapasin variants to enhance MHC-I antigen presentation.The Journal of biological chemistry · 2026Article
- HLA-Shuttle: A system for enhancing antigen presentation in immunologically cold tumors.Science advances · 2026Article
- Mouse TAPBPR shows functional similarity to human TAPBPR in shaping the MHC-I immunopeptidome.Frontiers in immunology · 2026Article
- SARS-CoV-2 ORF8: an accessory protein at the interface of immune evasion and inflammation.Frontiers in immunology · 2026Review
- Can the simple chicken MHC provide insight into the balance of autoimmunity and infectious disease?Immunogenetics · 2025Review
- High resolution class I HLA-A, -B, and -C diversity in Eastern and Southern African populations.Scientific reports · 2025Article
- Effects of Calreticulin Mutations on HLA Class I Expression in Myeloproliferative Neoplasms.bioRxiv : the preprint server for biology · 2025Article
- Acute infectious mononucleosis generates persistent, functional EBNA-1 antibodies with high cross-reactivity to alpha-crystalline beta.Cell reports · 2025Article
- Loss of Tapasin in Tumors Potentiates T-Cell Recognition and Anti-Tumor Effects of Immune Checkpoint Blockade.Cancer science · 2025Article
- Emerging biochemical, microbial and immunological evidence in the search for why HLA-BCell chemical biology · 2025Review
- CryoEM structure of an MHC-I/TAPBPR peptide-bound intermediate reveals the mechanism of antigen proofreading.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Viral manipulation of the HLA class I antigen processing and presentation pathway.Frontiers in immunology · 2025Review
- Evidence of focusing the MHC class I immunopeptidome by tapasin.Frontiers in immunology · 2025Article
- Deep learning enhances the prediction of HLA class I-presented CD8Nature machine intelligence · 2025Article
- TAPBPR promotes editing of the HLA-B44 peptide repertoire, increasing the presentation of peptides containing a C-terminal tryptophan.Frontiers in immunology · 2025Article
- Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning.eLife · 2024Article
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Authors and funding
28 authors at 18 institutions in 3 countries.
Arman A BashirovaBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702.
Mathias ViardBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702.ORCID 0000-0002-1737-8021
Vivek NaranbhaiDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215.ORCID 0000-0003-4281-8882
Alba GrifoniDivision of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037.ORCID 0000-0002-2209-5966
Wilfredo Garcia-BeltranRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139.
Marjan AkdagBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702.
Yuko YukiBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702.ORCID 0000-0003-1721-6003
Xiaojiang GaoBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702.
Colm O'hUiginBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702.
Malini RaghavanDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.ORCID 0000-0002-1345-9318
Steven WolinskyDivision of Infectious Diseases, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
Jay H BreamDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205.ORCID 0000-0002-9149-7643
Priya DuggalDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205.
Jeremy MartinsonDepartment of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261.ORCID 0000-0003-4673-7238
Nelson L MichaelUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
Gregory D KirkDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205.
Susan P BuchbinderHIV Research Section, San Francisco Department of Public Health, San Francisco, CA 94102.
David HaasDepartment of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37204.
James J GoedertInfections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850.
Steven G DeeksDepartment of Medicine, University of California, San Francisco, CA 94110.
Jacques FellaySchool of Life Sciences, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.ORCID 0000-0002-8240-939X
Bruce WalkerRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139.ORCID 0000-0001-6122-9245
Philip GoulderDepartment of Paediatrics, University of Oxford, Oxford, OX1 4AJ, United Kingdom.
Peter CresswellDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06520.ORCID 0000-0003-0540-2351
Tim ElliottInstitute for Life Sciences, University of Southampton, Southampton, SO17 1BJ, United Kingdom.ORCID 0000-0003-1097-0222
Alessandro SetteDivision of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037.
Jonathan CarlsonImmunomics, Microsoft Healthcare NExT, Redmond, WA 98052.
Mary CarringtonBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702; carringm@mail.nih.gov.ORCID 0000-0002-2692-2180
Frederick National Laboratory for Cancer Research · USJohns Hopkins University · USRagon Institute of MGH, MIT and Harvard · USLa Jolla Institute for Immunology · USDana-Farber Cancer Institute · USMicrosoft (United States) · USNational Institutes of Health · USNorthwestern University · USSan Francisco Department of Public Health · USSIB Swiss Institute of Bioinformatics · CHUniversity of California, San Francisco · USUniversity of Michigan · USUniversity of Oxford · GBUniversity of Pittsburgh · USUniversity of Southampton · GBVanderbilt University · USWalter Reed Army Institute of Research · USYale University · US
Funding
Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/UM1AI068636 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, RAJESH T GANDHI · 2011 to 2026
$1073.1MVirology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6MNorthwestern CORE Clinical Research Site: Trans-omics for HIV/AIDS ResearchU01HL146240 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Frank J Palella, Valentina Stosor · 2019 to 2026
$31.5MIMMUNE EPITOPE AND ANALYSIS PROGRAM: Transplantation of organs, tissues and cells 75N93019C00001 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI WILSON, STEPHEN · 2019 to 2025
$23.1MINTERACTIONS &MECHANISMS OF FUNCTION OF THE TAP COMPLEXR01AI044115 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MALINI RAGHAVAN · 1999 to 2026
$9.3MMaximising Cure Potential in Paediatric HIV InfectionR01AI133673 · NIAID · UNIVERSITY OF OXFORD · PI GOULDER, PHILIP J · 2017 to 2021
$1.4MCCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENHLBI NIH HHS U01 HL146240NIAID NIH HHS 75N93019C00001NIAID NIH HHS HHSN272201400045CNIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI044115NIAID NIH HHS R01 AI133673NIAID NIH HHS UM1 AI068636
Abstract
Human leukocyte antigen (HLA) class I allotypes vary in their ability to present peptides in the absence of tapasin, an essential component of the peptide loading complex. We quantified tapasin dependence of all allotypes that are common in European and African Americans (
Indexed as
Histocompatibility Antigens Class IHIV InfectionsMembrane Transport ProteinsAntigen PresentationHIV-1Human Immunodeficiency Virus ProteinsHumansPeptidesT-Lymphocytes, CytotoxicViral LoadHistocompatibility Antigens Class IHuman Immunodeficiency Virus ProteinsMembrane Transport ProteinsPeptidestapasinHLApeptide repertoiretapasin
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.