Evidence map›Paper›PMID 33101284›Full record

Observational studyFrontiers in immunology2020

Increased Regulatory T Cells Precede the Development of Bronchopulmonary Dysplasia in Preterm Infants.

Julia Pagel, Nele Twisselmann, Tanja K Rausch, Silvio Waschina, Annika Hartz, Magdalena Steinbeis, Jonathan Olbertz, Kathrin Nagel, Alena Steinmetz, Kirstin Faust and 5 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 35 citations in OpenAlex.

  1. Development of a peripheral blood transcriptomic gene signature to predict bronchopulmonary dysplasia.American journal of physiology. Lung cellular and molecular physiology · 2023
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  16. Look Who's Talking: Host and Pathogen Drivers ofInternational journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Julia PagelDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
Nele TwisselmannDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
Tanja K RauschDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
Silvio WaschinaResearch Group Medical Systems Biology, Christian-Albrechts-University Kiel, Kiel, Germany.
Annika HartzDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
Magdalena SteinbeisDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
Jonathan OlbertzDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
Kathrin NagelDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
Alena SteinmetzDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
Kirstin FaustDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
Martin DemmertDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
Wolfgang GöpelDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
Egbert HertingDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
Jan RuppDepartment of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.
Christoph HärtelDepartment of Pediatrics, University of Lübeck, Lübeck, Germany.
University of Lübeck · DEChristian-Albrechts-Universität zu Kiel · DEGerman Center for Infection Research · DEUniversität Hamburg · DEUniversity of Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulatory T cells (Tregs) are important for the ontogenetic control of immune activation and tissue damage in preterm infants. However, the role of Tregs for the development of bronchopulmonary dysplasia (BPD) is yet unclear. The aim of our study was to characterize CD4+ CD25+ forkhead box protein 3 (FoxP3)+ Tregs in peripheral blood of well-phenotyped preterm infants (

Indexed as

AdultBronchopulmonary DysplasiaCohort StudiesFemaleFlow CytometryForkhead Transcription FactorsGestational AgeHLA-DR AntigensHumansImmunophenotypingInfant, NewbornInfant, PrematureInterleukin-2 Receptor alpha SubunitLymphocyte ActivationPregnancyT-Lymphocytes, RegulatoryForkhead Transcription FactorsFOXP3 protein, humanHLA-DR AntigensInterleukin-2 Receptor alpha SubunitBPDbronchopulmonary dysplasiaFoxp3neonatepreterm infantregulatory T cellsTregs

Identifiers

PMID33101284
PMCPMC7554370
OpenAlexW3090580626

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.