Evidence map›Paper›PMID 33102474›Full record

ArticleFrontiers in cell and developmental biology2020

Oct4 Regulates the Transition of Cancer Stem-Like Cells to Tumor Endothelial-Like Cells in Human Liver Cancer.

Hong-Lin Liu, Hong-Ting Tang, Han-Lin Yang, Ting-Ting Deng, Ya-Ping Xu, Shi-Qing Xu, Liang Peng, Zai Wang, Qing Fang, Xiao-Yan Kuang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

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  11. Expression ofFrontiers in oncology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Hong-Lin LiuInstitute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.
Hong-Ting TangInstitute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.
Han-Lin YangInstitute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.
Ting-Ting DengInstitute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.
Ya-Ping XuInstitute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.
Shi-Qing XuInstitute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.
Liang PengInstitute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.
Zai WangInstitute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.
Qing FangInstitute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.
Xiao-Yan KuangInstitute of Clinical Pathology, Zunyi Medical College, Zunyi, China.
Qin-Shan LiDepartment of Obstetrics and Gynecology, Prenatal Diagnosis Center, Affiliated Hospital of Guizhou Medical University, Guiyang, China.
China-Japan Friendship Hospital · CNAffiliated Hospital of Guizhou Medical University · CNZunyi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Octamer-binding transcription factor 4 (Oct4) has been recently implicated as a proangiogenic regulator in several induced pluripotent stem cells (iPSCs), however, its role in cancer stem-like cells (CSCs) remain unclear. We report here that Oct4 participates in tumor vasculogenesis in liver CSCs (LCSCs). We identify that LCSCs possess the potential of endothelial

Indexed as

cancer stem-like cellsendothelial trans-differentiationOct4transitionvasculogenesis

Identifiers

PMID33102474
PMCPMC7554317
OpenAlexW3090319795

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.