ArticleeLife2020
Variation of connectivity across exemplar sensory and associative thalamocortical loops in the mouse.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- Divergent representation and processing of task cues in sensory and prefrontal cortices of preterm-born mice.Nature communications · 2026Article
- The neural basis for uncertainty processing in hierarchical decision making.Nature communications · 2025Article
- Thalamic regulation of reinforcement learning strategies across prefrontal-striatal networks.Nature communications · 2025Article
- Article
- The Cortical Structural Model Extends to Thalamocortical Connections.The European journal of neuroscience · 2025Article
- The spatial extent of anatomical connections within the thalamus varies across the cortical hierarchy in humans and macaques.bioRxiv : the preprint server for biology · 2025Article
- A multimodal characterization of low-dimensional thalamocortical structural connectivity patterns.Communications biology · 2025Article
- Article
- A prefrontal thalamocortical readout for conflict-related executive dysfunction in schizophrenia.Cell reports. Medicine · 2024Article
- Rapid context inference in a thalamocortical model using recurrent neural networks.Nature communications · 2024Article
- Network state changes in sensory thalamus represent learned outcomes.Nature communications · 2024Article
- A Reconsideration of the Core and Matrix Classification of Thalamocortical Projections.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- The Associative Thalamus: A Switchboard for Cortical Operations and a Promising Target for Schizophrenia.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Analyzing Thalamocortical Tract-Tracing Experiments in a Common Reference Space.Neuroinformatics · 2024Article
- Non-severe thermal burn injuries induce long-lasting downregulation of gene expression in cortical excitatory neurons and microglia.Frontiers in molecular neuroscience · 2024Article
- Thalamocortical loops as temporal demodulators across senses.Communications biology · 2023Review
- Monosynaptic trans-collicular pathways link mouse whisker circuits to integrate somatosensory and motor cortical signals.PLoS biology · 2023Article
- Modulation of prefrontal couplings by prior belief-related responses in ventromedial prefrontal cortex.Frontiers in neuroscience · 2023Article
- Cerebellar and basal ganglia inputs define three main nuclei in the mouse ventral motor thalamus.Frontiers in neuroanatomy · 2023Article
- Anatomical identification of a corticocortical top-down recipient inhibitory circuitry by enhancer-restricted transsynaptic tracing.Frontiers in neural circuits · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The thalamus engages in sensation, action, and cognition, but the structure underlying these functions is poorly understood. Thalamic innervation of associative cortex targets several interneuron types, modulating dynamics and influencing plasticity. Is this structure-function relationship distinct from that of sensory thalamocortical systems? Here, we systematically compared function and structure across a sensory and an associative thalamocortical loop in the mouse. Enhancing excitability of mediodorsal thalamus, an associative structure, resulted in prefrontal activity dominated by inhibition. Equivalent enhancement of medial geniculate excitability robustly drove auditory cortical excitation. Structurally, geniculate axons innervated excitatory cortical targets in a preferential manner and with larger synaptic terminals, providing a putative explanation for functional divergence. The two thalamic circuits also had distinct input patterns, with mediodorsal thalamus receiving innervation from a diverse set of cortical areas. Altogether, our findings contribute to the emerging view of functional diversity across thalamic microcircuits and its structural basis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.