Evidence map›Paper›PMID 33106327›Full record

ArticleDisease models & mechanisms2020

Modulating the endoplasmic reticulum stress response attenuates neurodegeneration in a

James J Doyle, Celine Vrancx, Claudia Maios, Audrey Labarre, Shunmoogum A Patten, J Alex Parker

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. IndividualLife science alliance · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

James J DoyleDivision of Experimental Medicine, McGill University, Montreal, Quebec H4A 3J1, Canada.
Celine VrancxCentre de Recherche du Centre Hospitalier de l'Université de Montréal and Department of Neuroscience, University of Montreal, Montreal, Quebec H2X 0A9, Canada.
Claudia MaiosCentre de Recherche du Centre Hospitalier de l'Université de Montréal and Department of Neuroscience, University of Montreal, Montreal, Quebec H2X 0A9, Canada.
Audrey LabarreCentre de Recherche du Centre Hospitalier de l'Université de Montréal and Department of Neuroscience, University of Montreal, Montreal, Quebec H2X 0A9, Canada.
Shunmoogum A PattenINRS-Institut Armand-Frappier, Laval, Quebec H7V 1B7, Canada.
J Alex ParkerCentre de Recherche du Centre Hospitalier de l'Université de Montréal and Department of Neuroscience, University of Montreal, Montreal, Quebec H2X 0A9, Canada ja.parker@umontreal.ca.ORCID 0000-0002-3333-2445
Centre Hospitalier de l’Université de Montréal · CAInstitut National de la Recherche Scientifique · CAMcGill University Health Centre · CA

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
CIHRNIH HHS P40 OD010440
6 · The paper itself

Abstract

Spinal muscular atrophy (SMA) is a devastating autosomal recessive neuromuscular disease resulting in muscle atrophy and neurodegeneration, and is the leading genetic cause of infant death. SMA arises when there are homozygous deletion mutations in the human

Indexed as

Endoplasmic Reticulum StressAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsDisease Models, AnimalMotor NeuronsMuscle CellsMuscular Atrophy, SpinalNerve DegenerationNeuromuscular JunctionPhenotypePoint MutationSmall Molecule LibrariesSurvival of Motor Neuron 1 ProteinCaenorhabditis elegans ProteinsSmall Molecule Librariessmn-1 protein, C elegansSurvival of Motor Neuron 1 ProteinCaenorhabditis elegansER stressGeneticsMuscle pathologySpinal muscular atrophy

Identifiers

PMID33106327
PMCPMC7774902
OpenAlexW3092094306

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.