Evidence map›Paper›PMID 33108270›Full record

Trial reportJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2021

Patients with idiopathic pulmonary fibrosis with and without obstructive sleep apnea: differences in clinical characteristics, clinical outcomes, and the effect of PAP treatment.

George Papadogiannis, Izolde Bouloukaki, Charalampos Mermigkis, Stylianos Michelakis, Christina Ermidou, Eleni Mauroudi, Violeta Moniaki, Nikolaos Tzanakis, Katerina M Antoniou, Sophia E Schiza

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01637831 (CPAP Therapy in Patients With Idiopathic Pulmonary Fibrosis and Obstructive Sleep Apnea. Does It Offer a Better Quality of Life and Sleep?), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01637831 nacompletednot on this map

CPAP Therapy in Patients With Idiopathic Pulmonary Fibrosis and Obstructive Sleep Apnea. Does It Offer a Better Quality of Life and Sleep?

TypeinterventionalSponsorUniversity of CreteRan2010 to 2011Enrolled12ConditionsObstructive Sleep Apnea, Idiopathic Pulmonary FibrosisArmsContinuous Positive Airway Pressure (CPAP)
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  19. Towards Treatable Traits for Pulmonary Fibrosis.Journal of personalized medicine · 2022
    Review
  20. OSA and Chronic Respiratory Disease: Mechanisms and Epidemiology.International journal of environmental research and public health · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

George PapadogiannisSleep Disorders Center, Department of Respiratory Medicine, University of Crete, Heraklion, Greece.
Izolde BouloukakiSleep Disorders Center, Department of Respiratory Medicine, University of Crete, Heraklion, Greece.
Charalampos MermigkisSleep Disorders Center, Department of Respiratory Medicine, University of Crete, Heraklion, Greece.
Stylianos MichelakisSleep Disorders Center, Department of Respiratory Medicine, University of Crete, Heraklion, Greece.
Christina ErmidouSleep Disorders Center, Department of Respiratory Medicine, University of Crete, Heraklion, Greece.
Eleni MauroudiSleep Disorders Center, Department of Respiratory Medicine, University of Crete, Heraklion, Greece.
Violeta MoniakiSleep Disorders Center, Department of Respiratory Medicine, University of Crete, Heraklion, Greece.
Nikolaos TzanakisSleep Disorders Center, Department of Respiratory Medicine, University of Crete, Heraklion, Greece.
Katerina M AntoniouDepartment of Respiratory Medicine, Interstitial Lung Disease Unit, Pneumonology Molecular & Cellular Lab, Faculty of Medicine, University of Crete, Heraklion, Greece.
Sophia E SchizaSleep Disorders Center, Department of Respiratory Medicine, University of Crete, Heraklion, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesObstructive sleep apnea (OSA) in patients with idiopathic pulmonary fibrosis (IPF) is associated with worse mortality and clinical outcome. We aimed to assess differences between patients with IPF with and without OSA and the effect of positive airway pressure treatment on sleep and overall life quality, morbidity, and mortality in these patients.

methodsForty-five patients with newly diagnosed IPF underwent polysomnography. Using an apnea-hypopnea index ≥ 15 events/h for OSA diagnosis resulted in 16 patients with IPF and 29 with IPF-OSA. The patients completed the Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, Functional Outcomes in Sleep Questionnaire, Fatigue Severity Scale, Short Form-36 life questionnaire, and Beck Depression Inventory before and at the end of the follow-up period.

resultsPatients with IPF-OSA showed the most severe functional impairments in questionnaires, especially for General Health component of the Short Form-36 life questionnaire (37 vs 58, P = .03). At the 7-year follow-up, 16 (36%) patients had died, 6 (38%) in the IPF group and 10 (35%) in IPF-OSA group. Patients with ≥6-hour positive airway pressure use had better survival compared with patients with <6-hour use (P = .04). Significant improvement was also observed in Epworth Sleepiness Scale (3 vs 6, P = .03), Pittsburgh Sleep Quality Index (5 vs 8, P = .01), and Fatigue Severity Scale (37 vs 48, P = .008) score in patients with ≥4-hour positive airway pressure use.

conclusionsOSA plays a significant role on clinical features and quality of life in patients with IPF. Effective positive airway pressure treatment results in a significant improvement in sleepiness, fatigue, sleep quality, and mortality. CLINICAL

trial registrationRegistry: ClinicalTrials.gov; Name: CPAP Therapy in Patients With Idiopathic Pulmonary Fibrosis and Sleep Apnea; URL: https://clinicaltrials.gov/ct2/show/record/NCT01637831; Identifier: NCT01637831.

Indexed as

Idiopathic Pulmonary FibrosisSleep Apnea, ObstructiveContinuous Positive Airway PressureHumansPolysomnographyQuality of LifeTreatment Outcomeidiopathic pulmonary fibrosislife qualitymortalityobstructive sleep apneapositive airway pressuretreatment

Identifiers

PMID33108270
PMCPMC7927327

What Socratic holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.