ReviewCardiovascular intervention and therapeutics2021
Role of acetylcholine spasm provocation test as a pathophysiological assessment in nonobstructive coronary artery disease.
Review in Cardiovascular intervention and therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- The impact of mildly elevated HbA1c level, and low levels of high-density lipoprotein cholesterol and hemoglobin on microvascular angina.Heart and vessels · 2026Article
- Clinical Characteristics and Outcomes of Patients with a Positive Finding for the Coronary Spasm Provocation Test at Low Acetylcholine Doses.Internal medicine (Tokyo, Japan) · 2026Article
- Vasospastic Angina Masquerading as Plaque Erosion on Optical Coherence Tomography.JACC. Case reports · 2026Article
- Invasive Endotyping of Angina Pectoris with Nonobstructive Coronary Arteries.The International journal of angiology : official publication of the International College of Angiology, Inc · 2025Review
- Utilizing Cardiac Magnetic Resonance Imaging to Elucidate the Etiology of Sudden Cardiac Arrest.Internal medicine (Tokyo, Japan) · 2025Article
- Coronary Endothelial Dysfunction and Vasomotor Dysregulation in Myocardial Bridging.Journal of cardiovascular development and disease · 2025Review
- Relation of Perivascular Adipose Tissues on Computed Tomography to Coronary Vasospasm.Reviews in cardiovascular medicine · 2025Article
- Review
- Coronary Spasm Testing with Acetylcholine: A Powerful Tool for a Personalized Therapy of Coronary Vasomotor Disorders.Life (Basel, Switzerland) · 2024Review
- Do changes in intracoronary pressure aid coronary spasm diagnosis using the spasm provocation test?World journal of cardiology · 2024Article
- Thrombolysis in Myocardial Infarction Frame Count for Coronary Blood Flow Evaluation during Interventional Diagnostic Procedures.Medicina (Kaunas, Lithuania) · 2023Article
- Which Coronary Artery Should Be Preferred for Starting the Coronary Spasm Provocation Test?Life (Basel, Switzerland) · 2023Article
- Coronary Vascular (DYS) Function and Invasive Physiology Assessment: Insights into Bolus and Continuous Thermodilution Methods.Journal of clinical medicine · 2023Review
- Frequency and Clinical Impact of Family History of Coronary Artery Disease in Patients with Vasospastic Angina.Journal of cardiovascular development and disease · 2023Article
- Role of Dual-Acquisition Noninvasive Cardiac CT Imaging for the Detection of Vasospastic Angina.Journal of clinical medicine · 2023Article
- Influenza A(H1N1)pdm09 Virus Aggravates Pathology of Blood Vessels in Wistar Rats with Premorbid Acute Cardiomyopathy.Viruses · 2023Article
- Vasospastic angina in women: Clinical backgrounds and prognoses of patients younger than and older than 60 years.World journal of cardiology · 2023Article
- Japanese Herbal Medicine (Kampo) as a Possible Treatment for Ischemia With Non-obstructive Coronary Artery Disease.Cureus · 2023Review
- Repetitive catamenial myocardial infarction due to coronary artery spasm: a case report.European heart journal. Case reports · 2023Article
- 2023 Guidelines of the Taiwan Society of Cardiology on the Diagnosis and Management of Chronic Coronary Syndrome.Acta Cardiologica Sinica · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronary angiography (CAG) sometimes shows nonobstructive coronary arteries in patients with suspected angina or acute coronary syndrome (ACS). The high prevalence of nonobstructive coronary artery disease (CAD) in those patients has recently been reported not only in Japan but also in Western countries, and is clinically attracting attention. Coronary spasm is considered to be one of the leading causes of both suspected stable angina and ACS with nonobstructive coronary arteries. Coronary spasm could also be associated with left ventricular dysfunction leading to heart failure, which could be improved following the administration of calcium channel blockers. Because we rarely capture spontaneous attacks of coronary spasm with electrocardiograms or Holter recordings, an invasive diagnostic modality, acetylcholine (ACh) provocation test, can be useful in detecting coronary spasm during CAG. Furthermore, we can use the ACh-provocation test to identify high-risk patients with coronary spasm complicated with organic coronary stenosis, and then treat with intensive care. Nonobstructive CAD includes not only epicardial coronary spasm but also microvascular spasm or dysfunction that can be associated with recurrent anginal attacks and poor quality of life. ACh-provocation test could also be helpful for the assessment of microvascular spasm or dysfunction. We hope that cardiologists will increasingly perform ACh-provocation test to assess the pathophysiology of nonobstructive CAD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.