ArticleScientific reports2020
Effects of long-lasting social isolation and re-socialization on cognitive performance and brain activity: a longitudinal study in Octodon degus.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Social Behavior and Neurogenesis.International journal of molecular sciences · 2026Review
- IntelliProfiler: a research workflow for analyzing multiple animals with a high-resolution home-cage RFID system.Lab animal · 2026Article
- Nutritional modulation of host physiology, behavior, and gut microbiome in the captive rodent Octodon degus.Scientific reports · 2025Article
- Habituation with apparatus and group testing improves assessment of fish preferences.Journal of fish biology · 2025Article
- Better together than alone: sociality mitigates the negative impact of early family disruption on adult problem-solving performance in zebra finches.Proceedings. Biological sciences · 2025Article
- A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretion.Neuron · 2025Article
- How the forebrain transitions to adulthood: developmental plasticity markers in a long-lived rodent reveal region diversity and the uniqueness of adolescence.Frontiers in neuroscience · 2024Article
- Long-term behavioral effects of social separation during early life in a social mammal, Octodon degus.Scientific reports · 2023Article
- Age-Dependent Behavioral and Synaptic Dysfunction Impairment Are Improved with Long-Term Andrographolide Administration in Long-Lived Female Degus (International journal of molecular sciences · 2023Article
- Hearing and sociality: the implications of hearing loss on social life.Frontiers in neuroscience · 2023Review
- Impact of prolonged chronic social isolation stress on behavior and multifractal complexity of metabolic rate inFrontiers in behavioral neuroscience · 2023Article
- Effects of long-term individual housing of middle-aged femaleFrontiers in behavioral neuroscience · 2023Article
- Long-term social isolation stress exacerbates sex-specific neurodegeneration markers in a natural model of Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- Let's Be Ready: COVID-19 Related Restrictions Can Lead to an Outbreak of Social-Communication Problems in Children.Iranian journal of psychiatry · 2022Article
- Leveraging Social Networks for the Assessment and Management of Neurological Patients.Seminars in neurology · 2022Review
- The Effects of Aerobic Exercise Training on Cerebrovascular and Cognitive Function in Sedentary, Obese, Older Adults.Frontiers in aging neuroscience · 2022Article
- Regular Low-Intensity Exercise Prevents Cognitive Decline and a Depressive-Like State Induced by Physical Inactivity in Mice: A New Physical Inactivity Experiment Model.Frontiers in behavioral neuroscience · 2022Article
- Differential Role of Sex and Age in the Synaptic Transmission of Degus (Frontiers in integrative neuroscience · 2022Article
- Evolution and function of neurocognitive systems in non-human animals.Scientific reports · 2021Article
- The Long-Term Public Health Impact of Social Distancing on Brain Health: Topical Review.International journal of environmental research and public health · 2021Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Social isolation is considered a stressful situation that results in increased physiological reactivity to novel stimuli, altered behaviour, and impaired brain function. Here, we investigated the effects of long-term social isolation on working memory, spatial learning/memory, hippocampal synaptic transmission, and synaptic proteins in the brain of adult female and male Octodon degus. The strong similarity between degus and humans in social, metabolic, biochemical, and cognitive aspects, makes it a unique animal model that can be highly applicable for further social, emotional, cognitive, and aging studies. These animals were socially isolated from post-natal and post-weaning until adulthood. We also evaluated if re-socialization would be able to compensate for reactive stress responses in chronically stressed animals. We showed that long-term social isolation impaired the HPA axis negative feedback loop, which can be related to cognitive deficits observed in chronically stressed animals. Notably, re-socialization restored it. In addition, we measured physiological aspects of synaptic transmission, where chronically stressed males showed more efficient transmission but deficient plasticity, as the reverse was true on females. Finally, we analysed synaptic and canonical Wnt signalling proteins in the hypothalamus, hippocampus, and prefrontal cortex, finding both sex- and brain structure-dependent modulation, including transient and permanent changes dependent on stress treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.