ArticleScientific reports2020
Impaired mitochondrial medium-chain fatty acid oxidation drives periportal macrovesicular steatosis in sirtuin-5 knockout mice.
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Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Review
- Radiation-induced autophagy regulates fibroblast mitochondrial metabolism and crosstalk with triple-negative breast cancer cells.Cell reports · 2026Article
- Hippocampal Bioenergetics and Metabolic Profiling Identifies Fatty Acid Oxidation as a Potential Therapeutic Target in Traumatic Brain Injury.Molecular neurobiology · 2026Article
- Exercise and the hepatic sirtuin network: rethinking the research focus on SIRT1, SIRT3, and SIRT6.Frontiers in physiology · 2026Article
- Oral octanoylcarnitine alleviates exercise intolerance in mouse models of long-chain fatty acid oxidation disorders.JCI insight · 2025Article
- SIRT5 affects lipid accumulation in cells of a metabolic-associated fatty liver disease model by regulating the succinylation status of HSPD1.BMC immunology · 2025Article
- Tubular ACSM3 deficiency impairs medium-chain fatty acid metabolism and aggravates kidney fibrosis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD.Nature communications · 2024Article
- Pathogenesis and Management of Citrin Deficiency.Internal medicine (Tokyo, Japan) · 2024Review
- Differential Effects of Three Medium-Chain Fatty Acids on Mitochondrial Quality Control and Skeletal Muscle Maturation.Antioxidants (Basel, Switzerland) · 2024Article
- A High-Fat and High-Fructose Diet Exacerbates Liver Dysfunction by Regulating Sirtuins in a Murine Model.Life (Basel, Switzerland) · 2024Article
- Mitochondrial heterogeneity and adaptations to cellular needs.Nature cell biology · 2024Review
- Succinylation modification: a potential therapeutic target in stroke.Neural regeneration research · 2024Review
- A high-fat diet supplemented with medium-chain triglycerides ameliorates hepatic steatosis by reducing ceramide and diacylglycerol accumulation in mice.Experimental physiology · 2024Article
- Natural Phytochemicals as SIRT Activators-Focus on Potential Biochemical Mechanisms.Nutrients · 2023Review
- The role of hypoxia-inducible factor 1α in hepatic lipid metabolism.Journal of molecular medicine (Berlin, Germany) · 2023Review
- Post-translational modulation of cell signalling through protein succinylation.Exploration of targeted anti-tumor therapy · 2023Review
- Proteomics analyses of acute kidney injury biomarkers in a rat exertional heat stroke model.Frontiers in physiology · 2023Article
- The sirtuin family in health and disease.Signal transduction and targeted therapy · 2022Review
- Progress in Nonalcoholic Fatty Liver Disease: SIRT Family Regulates Mitochondrial Biogenesis.Biomolecules · 2022Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Eric S GoetzmanDepartment of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. eric.goetzman@chp.edu.
Sivakama S BharathiDepartment of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Yuxun ZhangDepartment of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Xue-Jun ZhaoDepartment of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Steven F DobrowolskiDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Kevin PeasleyDepartment of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Sunder Sims-LucasDepartment of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Satdarshan P MongaDivision of Experimental Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
University of Pittsburgh · USChildren's Hospital of Pittsburgh · US
Funding
Pittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Satdarshan Singh Monga · 2019 to 2026
$10.9MRole of Wnt/Beta-Catenin Signaling in Liver DevelopmentR01DK062277 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Satdarshan Singh Monga · 2004 to 2026
$9.0MRegulation of Peroxisomal Metabolism by Lysine AcylationR01DK090242 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GOETZMAN, ERIC S · 2011 to 2024
$5.4MThe role of Sirtuin 5 in acute kidney injuryR01DK121758 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SIMS-LUCAS, SUNDER · 2020 to 2024
$2.3MTargeting beta-catenin in liver pathology: Novel Interactions, Novel ParadigmsR01DK100287 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MONGA, SATDARSHAN SINGH · 2013 to 2016
$1.3MNIDDK NIH HHS 090242NIDDK NIH HHS P30 DK120531NIDDK NIH HHS R01 DK062277NIDDK NIH HHS R01 DK090242NIDDK NIH HHS R01 DK100287NIDDK NIH HHS R01 DK121758
Abstract
Medium-chain triglycerides (MCT), containing C
Indexed as
Acyl-CoA Dehydrogenase, Long-ChainAnimalsCoconut OilDietary FatsFatty AcidsFemaleMaleMiceMice, KnockoutMitochondria, LiverNon-alcoholic Fatty Liver DiseaseOxidation-ReductionSirtuinsTriglyceridesAcyl-CoA Dehydrogenase, Long-ChainCoconut OilDietary FatsFatty AcidsSIRT5 protein, mouseSirtuinsTriglycerides
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.