ReviewPulmonary circulation
Long-term chronic intermittent hypoxia: a particular form of chronic high-altitude pulmonary hypertension.
Review in Pulmonary circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Cardiopulmonary crosstalk in Long COVID: a systematic review of emerging evidence.BMC cardiovascular disorders · 2025Pooled it
- Clinical characteristics of patients with a risk of pulmonary artery hypertension secondary to ARDS in a high-altitude area.BMJ open respiratory research · 2023Trial
- Risk factors and outcomes of HPH in high-altitude residents via echocardiographic evaluation.BMC cardiovascular disorders · 2026Article
- Altitude hypoxia and hypoxemia: pathogenesis and management.Signal transduction and targeted therapy · 2026Review
- Research progress on high-altitude hypoxia pulmonary injury: pathogenesis and Chinese herbal medicine for prevention and treatment.Frontiers in pharmacology · 2026Review
- High altitude pulmonary hypertension: overlap with other types of pulmonary hypertension and implications for treatment.BMJ medicine · 2026Review
- Positive Airway Pressure Therapies and Oxygen Therapy in Obstructive Sleep Apnea (OSA): 5-Year Survival.Journal of clinical medicine · 2025Article
- Association between sleep disorders and osteoporosis in the elderly at high altitude in China.Sleep and biological rhythms · 2025Article
- Intravascular ultrasound evaluation of pulmonary hypertension in high-altitude patients with ventricular septal defect: a case report.Journal of medical case reports · 2025Article
- Closing the loop: autonomous intelligent control for hypoxia pre-acclimatization and high-altitude health management.National science review · 2025Review
- Advanced treatment strategies for high-altitude pulmonary hypertension employing natural medicines: A review.Journal of pharmaceutical analysis · 2025Review
- Machine learning-based integration develops an immune-derived signature for diagnosing high-altitude pulmonary hypertension.Frontiers in medicine · 2025Article
- Elevated Perspectives: Unraveling Cardiovascular Dynamics in High-Altitude Realms.Current cardiology reviews · 2025Review
- Review
- Biomechanical effects of hemin and sildenafil treatments on the aortic wall of chronic-hypoxic lambs.Frontiers in bioengineering and biotechnology · 2024Article
- Effects of Zinc on the Right Cardiovascular Circuit in Long-Term Hypobaric Hypoxia in Wistar Rats.International journal of molecular sciences · 2023Article
- Tensions in Taxonomies: Current Understanding and Future Directions in the Pathobiologic Basis and Treatment of Group 1 and Group 3 Pulmonary Hypertension.Comprehensive Physiology · 2023Review
- The role of NMDA glutamate receptors in lung injury caused by chronic long-term intermittent hypobaric hypoxia.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023Article
- Ethnicity Disparities in the Prevalence, Awareness, Treatment, and Control Rates of Hypertension in China.International journal of hypertension · 2023Article
- Pulmonary Capacity, Blood Composition and Metabolism among Coal Mine Workers in High- and Low-Altitude Aboveground and Underground Workplaces.International journal of environmental research and public health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In some subjects, high-altitude hypobaric hypoxia leads to high-altitude pulmonary hypertension. The threshold for the diagnosis of high-altitude pulmonary hypertension is a mean pulmonary artery pressure of 30 mmHg, even though for general pulmonary hypertension is ≥25 mmHg. High-altitude pulmonary hypertension has been associated with high hematocrit findings (chronic mountain sickness), and although these are two separate entities, they have a synergistic effect that should be considered. In recent years, a new condition associated with high altitude was described in South America named long-term chronic intermittent hypoxia and has appeared in individuals who commute to work at high altitude but live and rest at sea level. In this review, we discuss the initial epidemiological pattern from the early studies done in Chile, the clinical presentation and possible molecular mechanism and a discussion of the potential management of this condition.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.