ReviewAntioxidants (Basel, Switzerland)2020
Early Origins of Hypertension: Should Prevention Start Before Birth Using Natural Antioxidants?
Review in Antioxidants (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 40 citations in OpenAlex.
- Assessing Sarcocornia as a Salt Substitute: Effects on Lipid Profile and Gelatinase Activity.Nutrients · 2024Trial
- Essential Hypertension and Oxidative Stress: Novel Future Perspectives.International journal of molecular sciences · 2022Trial
- Redox-Driven Precision Medicine for Life-Course Prevention of Cardiovascular-Kidney-Metabolic Syndrome.Antioxidants (Basel, Switzerland) · 2026Review
- Oxidative stress and pediatric diabetic cardiovascular complications: emerging research and clinical applications.American journal of physiology. Heart and circulatory physiology · 2025Review
- Childhood Cardiovascular Health, Obesity, and Some Related Disorders: Insights into Chronic Inflammation and Oxidative Stress.International journal of molecular sciences · 2024Review
- Protective effects of the R-(+)-thioctic acid treatment: possible anti-inflammatory activity on heart of hypertensive rats.BMC complementary medicine and therapies · 2024Article
- Marine sourced tripeptide SRP and its sustained-release formulation SRP-PLGA-MS exhibiting antihypertensive effect in spontaneously hypertensive rats and HUVECs.Frontiers in nutrition · 2024Article
- Anti-Hypertensive Property of an NO Nanoparticle in an Adenine-Induced Chronic Kidney Disease Young Rat Model.Antioxidants (Basel, Switzerland) · 2023Article
- Comorbidity of Anxiety and Hypertension: Common Risk Factors and Potential Mechanisms.International journal of hypertension · 2023Review
- Perinatal Oxidative Stress and Kidney Health: Bridging the Gap between Animal Models and Clinical Reality.Antioxidants (Basel, Switzerland) · 2022Review
- Metabolic Syndrome Programming and Reprogramming: Mechanistic Aspects of Oxidative Stress.Antioxidants (Basel, Switzerland) · 2022Review
- Novel Insights on Dietary Polyphenols for Prevention in Early-Life Origins of Hypertension: A Review Focusing on Preclinical Animal Models.International journal of molecular sciences · 2022Review
- Systemic Inflammation, Oxidative Stress and Cardiovascular Health in Children and Adolescents: A Systematic Review.Antioxidants (Basel, Switzerland) · 2022Review
- Hypertension of Developmental Origins: Consideration of Gut Microbiome in Animal Models.Biomedicines · 2022Review
- Chronic Kidney Disease and Gut Microbiota: What Is Their Connection in Early Life?International journal of molecular sciences · 2022Review
- Oxidative Stress-Induced Hypertension of Developmental Origins: Preventive Aspects of Antioxidant Therapy.Antioxidants (Basel, Switzerland) · 2022Review
- The Impact of Gut Microbiome on Maternal Fructose Intake-Induced Developmental Programming of Adult Disease.Nutrients · 2022Review
- Early-Life Origins of Metabolic Syndrome: Mechanisms and Preventive Aspects.International journal of molecular sciences · 2021Review
- New Mechanisms of Action of Natural Antioxidants in Health and Disease II.Antioxidants (Basel, Switzerland) · 2021Article
- Antioxidant Properties of Alpha-Lipoic (Thioctic) Acid Treatment on Renal and Heart Parenchyma in a Rat Model of Hypertension.Antioxidants (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Hypertension may originate in early life. Reactive oxygen species (ROS) generated due to the exposure of adverse in utero conditions causes developmental programming of hypertension. These excessive ROS can be antagonized by molecules which are antioxidants. Prenatal use of natural antioxidants may reverse programming processes and prevent hypertension of developmental origin. In the current review, firstly we document data on the impact of oxidative stress in hypertension of developmental origin. This will be followed by effective natural antioxidants uses starting before birth to prevent hypertension of developmental origin in animal models. It will also discuss evidence for the common mechanisms underlying developmental hypertension and beneficial effects of natural antioxidant interventions used as reprogramming strategies. A better understanding of the reprogramming effects of natural antioxidants and their interactions with common mechanisms underlying developmental hypertension is essential. Therefore, pregnant mothers and their children can benefit from natural antioxidant supplementation during pregnancy in order to reduce their risk for hypertension later in life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.