Evidence map›Paper›PMID 33118348›Full record

ArticleJournal of natural products2020

Discovery of a Beetroot Protease Inhibitor to Identify and Classify Plant-Derived Cystine Knot Peptides.

Bernhard Retzl, Roland Hellinger, Edin Muratspahić, Meri E F Pinto, Vanderlan S Bolzani, Christian W Gruber

Open access · hybridAbstract read
In one paragraph

Article in Journal of natural products, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  4. Review
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  8. Review
  9. Frontiers in pharmacology · 2022
    Article
  10. Article
  11. Review
  12. Article
  13. Promoting Plant-Based Therapies for Chronic Kidney Disease.Journal of evidence-based integrative medicine
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Bernhard RetzlCenter for Physiology and Pharmacology, Medical University of Vienna, Schwarzspanierstraße 17, 1090 Vienna, Austria.ORCID 0000-0001-7764-7046
Roland HellingerCenter for Physiology and Pharmacology, Medical University of Vienna, Schwarzspanierstraße 17, 1090 Vienna, Austria.ORCID 0000-0002-8955-8793
Edin MuratspahićCenter for Physiology and Pharmacology, Medical University of Vienna, Schwarzspanierstraße 17, 1090 Vienna, Austria.ORCID 0000-0002-6011-0805
Meri E F PintoCenter for Physiology and Pharmacology, Medical University of Vienna, Schwarzspanierstraße 17, 1090 Vienna, Austria.ORCID 0000-0003-0663-0233
Vanderlan S BolzaniInstitute of Chemistry, São Paulo State University-UNESP, 14800-060, Araraquara, SP, Brazil.ORCID 0000-0001-7019-5825
Christian W GruberCenter for Physiology and Pharmacology, Medical University of Vienna, Schwarzspanierstraße 17, 1090 Vienna, Austria.ORCID 0000-0001-6060-7048
Medical University of Vienna · ATUniversidade Estadual Paulista (Unesp) · BR

Funding

Austrian Science Fund FWF I 3243Austrian Science Fund FWF P 32109
6 · The paper itself

Abstract

Plant peptide protease inhibitors are important molecules in seed storage metabolism and to fight insect pests. Commonly they contain multiple disulfide bonds and are exceptionally stable molecules. In this study, a novel peptide protease inhibitor from beetroot (

Indexed as

Drug DiscoveryAmino Acid SequenceBeta vulgarisCystinePeptidesPhylogenyPlant ProteinsProtease InhibitorsProteolysisSequence Homology, Amino AcidSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationCystinePeptidesPlant ProteinsProtease Inhibitors

Identifiers

PMID33118348
PMCPMC7705960
OpenAlexW3096508154

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.