Evidence map›Paper›PMID 33118933›Full record

RevieweLife2020

Lipid hijacking: a unifying theme in vector-borne diseases.

Anya J O'Neal, L Rainer Butler, Agustin Rolandelli, Stacey D Gilk, Joao Hf Pedra

Abstract readReview
In one paragraph

Review in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The inhibition mechanism ofFrontiers in microbiology · 2026
    Review
  5. ATF6 enables pathogen infection in ticks by inducingProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Lipid Trafficking in Diverse Bacteria.Accounts of chemical research · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Cholesterol Contributes to Risk, Severity, and Machine Learning-Driven Diagnosis of Lyme Disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  16. Article
  17. Croquemort elicits activation of the immune deficiency pathway in ticks.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. Reduced Cholesterol Levels during Acute Human Babesiosis.Pathogens (Basel, Switzerland) · 2023
    Article
  19. Regulation of phosphoinositide metabolism in Apicomplexan parasites.Frontiers in cell and developmental biology · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anya J O'NealDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, United States.ORCID 0000-0001-5188-1344
L Rainer ButlerDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, United States.
Agustin RolandelliDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, United States.ORCID 0000-0003-1059-3578
Stacey D GilkDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States.
Joao Hf PedraDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, United States.ORCID 0000-0001-8740-2667

Funding

Tick Resources CoreP01AI138949 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI UTPAL PAL · 2018 to 2026
$13.5M
Development of Paratransgenic Ticks for Disease ControlR01AI049424 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MUNDERLOH, ULRIKE GERTRUD · 2002 to 2022
$6.9M
Ubiquitylation and Rickettsial Colonization of a Tick VectorR01AI116523 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PEDRA, JOAO · 2016 to 2025
$6.2M
Tick Saliva and Pathogen TransmissionR01AI134696 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Joao Pedra · 2018 to 2026
$5.1M
Coxiella manipulation of lipids in the intracellular nicheR01AI139176 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI STACEY D GILK · 2018 to 2026
$2.6M
Characterization of a Lipid Receptor in Tick Humoral ImmunityF31AI152215 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI O’NEAL, ANYA JOSEPHINE · 2020 to 2021
$81k
NIAID NIH HHS F31 AI152215NIAID NIH HHS P01 AI138949NIAID NIH HHS R01 AI049424NIAID NIH HHS R01 AI116523NIAID NIH HHS R01 AI134696NIAID NIH HHS R01 AI139176
6 · The paper itself

Abstract

Vector-borne illnesses comprise a significant portion of human maladies, representing 17% of global infections. Transmission of vector-borne pathogens to mammals primarily occurs by hematophagous arthropods. It is speculated that blood may provide a unique environment that aids in the replication and pathogenesis of these microbes. Lipids and their derivatives are one component enriched in blood and are essential for microbial survival. For instance, the malarial parasite

Indexed as

Lipid MetabolismAnimalsBorreliaCulicidaeHumansInsectaTicksTrypanosomatinaVector Borne Diseasesarthropod vectorsinfectioninfectious diseasemicrobiologyvector-borne diseases

Identifiers

PMID33118933
PMCPMC7595734

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.