ArticleNeuron2021
Comparative Connectomics Reveals How Partner Identity, Location, and Activity Specify Synaptic Connectivity in Drosophila.
Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 66 citations in OpenAlex.
- The cellular basis of locomotor evolution: insights from larval insects.Current opinion in behavioral sciences · 2026Article
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- Maturation of GABAergic signalling times the opening of a critical period in Drosophila melanogaster.Scientific reports · 2025Article
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- Spatial constraints and cell surface molecule depletion structure a randomly connected learning circuit.Current biology : CB · 2025Article
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- Neural substrates of cold nociception ineLife · 2025Article
- Three systems of circuit formation: assembly, updating and tuning.Nature reviews. Neuroscience · 2025Review
- Comparative connectomics of the descending and ascending neurons of thebioRxiv : the preprint server for biology · 2024Article
- Simulation-based inference for efficient identification of generative models in computational connectomics.PLoS computational biology · 2023Article
- Input density tunes Kenyon cell sensory responses in the Drosophila mushroom body.Current biology : CB · 2023Article
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- The connectome of an insect brain.Science (New York, N.Y.) · 2023Article
- Connectomics and the neural basis of behaviour.Current opinion in insect science · 2022Review
- The chemosensory system of theFly · 2022Review
- Article
- Rapid reconstruction of neural circuits using tissue expansion and light sheet microscopy.eLife · 2022Article
- Sequential addition of neuronal stem cell temporal cohorts generates a feed-forward circuit in theeLife · 2022Article
- The two-body problem: Proprioception and motor control across the metamorphic divide.Current opinion in neurobiology · 2022Review
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
The mechanisms by which synaptic partners recognize each other and establish appropriate numbers of connections during embryonic development to form functional neural circuits are poorly understood. We combined electron microscopy reconstruction, functional imaging of neural activity, and behavioral experiments to elucidate the roles of (1) partner identity, (2) location, and (3) activity in circuit assembly in the embryonic nerve cord of Drosophila. We found that postsynaptic partners are able to find and connect to their presynaptic partners even when these have been shifted to ectopic locations or silenced. However, orderly positioning of axon terminals by positional cues and synaptic activity is required for appropriate numbers of connections between specific partners, for appropriate balance between excitatory and inhibitory connections, and for appropriate functional connectivity and behavior. Our study reveals with unprecedented resolution the fine connectivity effects of multiple factors that work together to control the assembly of neural circuits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.