Evidence map›Paper›PMID 33120974›Full record

SynthesisSensors (Basel, Switzerland)2020

A Systematic Review of Machine Learning Techniques in Hematopoietic Stem Cell Transplantation (HSCT).

Vibhuti Gupta, Thomas M Braun, Mosharaf Chowdhury, Muneesh Tewari, Sung Won Choi

Abstract readSystematic Review
In one paragraph

Synthesis in Sensors (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vibhuti GuptaMichigan Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-6221-4712
Thomas M BraunSchool of Public Health, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Mosharaf ChowdhuryMichigan Engineering, Computer Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-0884-6740
Muneesh TewariMichigan Medicine, Department of Internal Medicine, Hematology/Oncology Division, University of Michigan, Ann Arbor, MI 48109, USA.
Sung Won ChoiMichigan Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-6321-3834

Funding

Phase I/II clinical trial of HDAC inhibition for GVHD prevention in children, adolescents, and young adultsR01CA249211 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHOI, SUNG WON · 2020 to 2024
$2.2M
Roadmap 2.0: A randomized controlled trial using a technology-mediated platform in family caregivers of BMT patientsR01HL146354 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHOI, SUNG WON · 2019 to 2023
$1.8M
Patient-Oriented Research and Mentoring in Hematopoietic Cell TransplantationK24HL156896 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SUNG WON CHOI · 2021 to 2026
$870k
NCI NIH HHS R01 CA249211NHLBI NIH HHS K24 HL156896NHLBI NIH HHS R01 HL146354NIH/NHBLI 1R01HL146354
6 · The paper itself

Abstract

Machine learning techniques are widely used nowadays in the healthcare domain for the diagnosis, prognosis, and treatment of diseases. These techniques have applications in the field of hematopoietic cell transplantation (HCT), which is a potentially curative therapy for hematological malignancies. Herein, a systematic review of the application of machine learning (ML) techniques in the HCT setting was conducted. We examined the type of data streams included, specific ML techniques used, and type of clinical outcomes measured. A systematic review of English articles using PubMed, Scopus, Web of Science, and IEEE Xplore databases was performed. Search terms included "hematopoietic cell transplantation (HCT)," "autologous HCT," "allogeneic HCT," "machine learning," and "artificial intelligence." Only full-text studies reported between January 2015 and July 2020 were included. Data were extracted by two authors using predefined data fields. Following PRISMA guidelines, a total of 242 studies were identified, of which 27 studies met the inclusion criteria. These studies were sub-categorized into three broad topics and the type of ML techniques used included ensemble learning (63%), regression (44%), Bayesian learning (30%), and support vector machine (30%). The majority of studies examined models to predict HCT outcomes (e.g., survival, relapse, graft-versus-host disease). Clinical and genetic data were the most commonly used predictors in the modeling process. Overall, this review provided a systematic review of ML techniques applied in the context of HCT. The evidence is not sufficiently robust to determine the optimal ML technique to use in the HCT setting and/or what minimal data variables are required.

Indexed as

Graft vs Host DiseaseHematopoietic Stem Cell TransplantationMachine LearningBayes TheoremHumansartificial intelligencehematopoietic stem cell transplantationHSCTmachine learningmHealthmobile healthsensors

Identifiers

PMID33120974
PMCPMC7663237

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.