Evidence map›Paper›PMID 33124670›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2021

Body Composition is Associated With Islet Function After Pancreatectomy and Islet Autotransplantation for Pancreatitis.

Tasma Harindhanavudhi, Yi Yang, James S Hodges, Timothy L Pruett, Varvara Kirchner, Gregory J Beilman, Melena D Bellin

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Nutritional Risks in Patients Undergoing Total Pancreatectomy Islet AutoTransplantation in the POST Consortium.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023
    Observational
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tasma HarindhanavudhiDivision of Diabetes and Endocrinology, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.
Yi YangDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota.
James S HodgesDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota.
Timothy L PruettDepartment of Surgery, University of Minnesota, Minneapolis, Minnesota.
Varvara KirchnerDepartment of Surgery, University of Minnesota, Minneapolis, Minnesota.
Gregory J BeilmanDepartment of Surgery, University of Minnesota, Minneapolis, Minnesota.
Melena D BellinDepartment of Surgery, University of Minnesota, Minneapolis, Minnesota.
University of Minnesota · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
Sitagliptin therapy to improve outcomes after islet autotransplantation.K23DK084315 · NIDDK · UNIVERSITY OF MINNESOTA · PI BELLIN, MELENA D. · 2010 to 2014
$816k
NCATS NIH HHS UL1 TR002494NIDDK NIH HHS K23 DK084315
6 · The paper itself

Abstract

contextBody composition in total pancreatectomy with islet autotransplantation (TPIAT) has never been studied.

objectiveDetermine whether presurgical body composition is associated with islet function and insulin sensitivity after TPIAT.

methodsIn 88 adults undergoing TPIAT (median age 41.0 years, IQR 32.8-48.0), beta-cell function and insulin sensitivity were assessed using mixed meal tolerance test and frequent sample intravenous glucose tolerance test before surgery and 12 and 18 months afterward. Body composition was measured by dual x-ray absorptiometry. Analyses used linear and logistic regression.

resultsBefore surgery, 8 individuals (9.1%) were underweight, 40 (45.5%) normal weight, 20 (22.7%) overweight, and 20 (22.7%) obese. Overweight/obese patients had higher area under the curve C-peptide and lower insulin sensitivity index. Baseline body weight was positively associated with first-phase insulin secretion (AIRg) at 12 months (average 38.5 [SE 17.1] mU/L/min higher per extra kg; P = 0.03) and 18 months (38.3 [18.5]; P = 0.04), while baseline lean mass was inversely associated with AIRg at 12 months (-0.05 [0.02] per extra kg; P = 0.01) and 18 months (-0.05 [0.02]; P = 0.03). Percent gynoid fat was inversely associated with disposition index at 18 months (-206.0 [97.2] per extra percent; P = 0.04). Percent body fat and percent gynoid fat were associated with glucose effectiveness index at 18 months (1.9 × 10-3 [0.9 × 10-3] per extra percent; P = 0.04 and -1.96 × 10-3 [0.8 × 10-3]; P = 0.02, respectively). Insulin independence was not significantly associated with body weight or composition.

conclusionsHalf of these chronic pancreatitis patients were overweight/obese; underweight was uncommon. Preoperative body weight and composition were associated with islet function but not insulin independence after TPIAT.

Indexed as

Islets of Langerhans TransplantationPancreatectomyAdultBody CompositionBody Mass IndexFemaleFollow-Up StudiesGraft SurvivalHumansInsulin ResistanceIslets of LangerhansMaleMiddle AgedMinnesotaPancreatitis, ChronicTransplantation, Autologousbody compositionobesitytotal pancreatectomy with islet autotransplantation

Identifiers

PMID33124670
PMCPMC7823238
OpenAlexW3095160121

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.