Evidence map›Paper›PMID 33128044›Full record

ReviewNature reviews. Cardiology2021

Cardiovascular disease in patients with severe mental illness.

René Ernst Nielsen, Jytte Banner, Svend Eggert Jensen

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05659498 (Cardiac Rehabilitation for Cardiovascular Risk Reduction in People With Severe and Persistent Mental Illness), which is not on this map. Cited by 201 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
201citing papers in PubMed, 8 pooled it
25.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05659498 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Cardiac Rehabilitation for Cardiovascular Risk Reduction in People With Severe and Persistent Mental Illness: A Pilot Randomized Study

TypeinterventionalSponsorLady Davis InstituteRan2022 to 2024Enrolled46ConditionsMental Illness Persistent, Cardiovascular PreventionArmsCardiac Rehabilitation Program
3 · Its place in the literature

Who cites it

201 citing papers in PubMed, 8 syntheses or guidelines pooled it, 363 citations in OpenAlex.

  1. Pooled it
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  8. Outcomes associated with different vaccines in individuals with bipolar disorder and impact on the current COVID-19 pandemic- a systematic review.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2022
    Pooled it
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  11. Observational
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  13. [Patient navigation in severe mental illness-challenges, models, and perspectives].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2026
    Review
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141 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

René Ernst NielsenDepartment of Clinical Medicine, Aalborg University, Aalborg, Denmark. ren@rn.dk.ORCID http://orcid.org/0000-0002-7982-6352
Jytte BannerDepartment of Forensic Medicine, University of Copenhagen, Copenhagen, Denmark.
Svend Eggert JensenDepartment of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Aalborg University Hospital · DKUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Individuals diagnosed with schizophrenia or bipolar disorder have a life expectancy 15-20 years shorter than that in the general population. The rate of unnatural deaths, such as suicide and accidents, is high for these patients. Despite this increased proportion of unnatural deaths, physical conditions account for approximately 70% of deaths in patients with either schizophrenia or bipolar disorder, with cardiovascular disease contributing 17.4% and 22.0% to the reduction in overall life expectancy in men and women, respectively. Risk factors for cardiovascular disease, such as smoking, unhealthy diet and lack of exercise, are common in these patients, and lifestyle interventions have been shown to have small effects. Pharmacological interventions to reduce risk factors for cardiovascular disease have been proven to be effective. Treatment with antipsychotic drugs is associated with reduced mortality but also with an increased risk of weight gain, dyslipidaemia and diabetes mellitus. These patients have higher risks of both myocardial infarction and stroke but a lower risk of undergoing interventional procedures compared with the general population. Data indicate a negative attitude from clinicians working outside the mental health fields towards patients with severe mental illness. Education might be a possible method to decrease the negative attitudes towards these patients, thereby improving their rates of diagnosis and treatment.

Indexed as

Bipolar DisorderCardiovascular DiseasesSchizophreniaHumansLife ExpectancyMental DisordersRisk AssessmentRisk FactorsRisk Reduction Behavior

Identifiers

PMID33128044
OpenAlexW3096063139

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.