Evidence map›Paper›PMID 33128172›Full record

ReviewBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2021

Copper metabolism in Saccharomyces cerevisiae: an update.

Hua Shi, Yunhui Jiang, Yang Yang, Yougong Peng, Chenghua Li

Abstract readReview
PubMed Publisher
In one paragraph

Review in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 78 citations in OpenAlex.

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  14. Inhibitory effect of copper chelators on the budding inAntimicrobial agents and chemotherapy · 2025
    Article
  15. Family Identification and Functional Study of Copper Transporter Genes inInternational journal of molecular sciences · 2024
    Article
  16. Review
  17. Article
  18. Article
  19. Effect ofHeliyon · 2024
    Article
  20. The Contribution ofFoods (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hua ShiCenter of Growth, Metabolism and Aging, Key Laboratory of Biological Resources and Ecological Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610065, China.
Yunhui JiangPathology Department, The Second People's Hospital of Jingmen, Jingmen, 448000, China.
Yang YangDepartment of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Yougong PengDepartment of General Surgery, The Second People's Hospital of Jingmen, Jingmen, 448000, China.
Chenghua LiCenter of Growth, Metabolism and Aging, Key Laboratory of Biological Resources and Ecological Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610065, China. lichenghua@scu.edu.cn.ORCID 0000-0001-7096-6845
Sichuan University · CNFirst People’s Hospital of Jingmen · CN

Funding

National Natural Science Foundation of China (CN) 91749121the Fundamental Research Funds for Central Universities SCU2019C4005the Fundamental Research Funds for Central Universities SCU2019D013the Outstanding Young and Middle-aged Scientific and Technological Innovation Team Program of the Colleges and Universities in Hubei Provinc T201819
6 · The paper itself

Abstract

Copper is an essential element in all forms of life. It acts as a cofactor of some enzymes and is involved in forming proper protein conformations. However, excess copper ions in cells are detrimental as they can generate free radicals or disrupt protein structures. Therefore, all life forms have evolved conserved and exquisite copper metabolic systems to maintain copper homeostasis. The yeast Saccharomyces cerevisiae has been widely used to investigate copper metabolism as it is convenient for this purpose. In this review, we summarize the mechanism of copper metabolism in Saccharomyces cerevisiae according to the latest literature. In brief, bioavailable copper ions are incorporated into yeast cells mainly via the high-affinity transporters Ctr1 and Ctr3. Then, intracellular Cu

Indexed as

CopperSaccharomyces cerevisiaeCopperChaperoneCopperHomeostasisMetabolismSaccharomyces cerevisiaeTransporter

Identifiers

PMID33128172
OpenAlexW3095607429

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.