Evidence map›Paper›PMID 33129204›Full record

ArticlePurinergic signalling2020

Nucleotide P2Y

Theodore E Liston, Sonja Hinz, Christa E Müller, Deborah M Holstein, Jay Wendling, Roger J Melton, Mary Campbell, William S Korinek, R Rama Suresh, Dane A Sethre-Hofstad and 4 more

Open access · greenAbstract read
In one paragraph

Article in Purinergic signalling, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Selective modulation of epileptic tissue by an adenosine ABritish journal of pharmacology · 2024
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  5. Extrahelical Binding Site for a 1Molecular pharmacology · 2024
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  6. Extracellular ATP Neurotransmission and Nicotine Sex-Specifically Modulate Habenular Neuronal Activity in Adolescence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
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  7. Assay-Dependent Inverse Agonism at the AACS pharmacology & translational science · 2023
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  8. First Potent Macrocyclic AACS pharmacology & translational science · 2023
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  9. Review
  10. Article
  11. Structure-Activity Studies of 1Journal of medicinal chemistry · 2022
    Article
  12. Review
  13. Selective AACS medicinal chemistry letters · 2022
    Article
  14. Development of Bicyclo[3.1.0]hexane-Based AMolecules (Basel, Switzerland) · 2022
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  15. Therapeutic Potential of Highly Selective AMolecules (Basel, Switzerland) · 2022
    Review
  16. Article
  17. Crosstalk Between ATP-PFrontiers in cellular neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Theodore E ListonAstrocyte Pharmaceuticals Inc., Suite 1800, 245 First Street, Cambridge, MA, 02142, USA. liston@astrocytepharma.com.ORCID 0000-0002-0828-797X
Sonja HinzPharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn, Germany.
Christa E MüllerPharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn, Germany.
Deborah M HolsteinUniversity of Texas Health at San Antonio, San Antonio, TX, USA.
Jay WendlingInotiv, Maryland Heights, MO, USA.
Roger J MeltonInotiv, Maryland Heights, MO, USA.
Mary CampbellInotiv, Maryland Heights, MO, USA.
William S KorinekAstrocyte Pharmaceuticals Inc., Suite 1800, 245 First Street, Cambridge, MA, 02142, USA.
R Rama SureshNational Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.
Dane A Sethre-HofstadAstrocyte Pharmaceuticals Inc., Suite 1800, 245 First Street, Cambridge, MA, 02142, USA.
Zhan-Guo GaoNational Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.
Dilip K ToshNational Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.
Kenneth A JacobsonNational Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.
James D LechleiterUniversity of Texas Health at San Antonio, San Antonio, TX, USA.
National Institute of Diabetes and Digestive and Kidney Diseases · USThe University of Texas Health Science Center at San Antonio · USUniversity of Bonn · DEIncyte (United States) · US

Funding

Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Intramural NIH HHS ZIA DK031117Intramural NIH HHS ZIADK31117NINDS NIH HHS R41NS0993756
6 · The paper itself

Abstract

Rapid phosphoester hydrolysis of endogenous purine and pyrimidine nucleotides has challenged the characterization of the role of P2 receptors in physiology and pathology. Nucleotide phosphoester stabilization has been pursued on a number of medicinal chemistry fronts. We investigated the in vitro and in vivo stability and pharmacokinetics of prototypical nucleotide P2Y

Indexed as

Adenosine A1 Receptor AgonistsAdenosine A3 Receptor AgonistsAdenosine DiphosphateAnimalsDeoxyadenine NucleotidesFemaleHumansMiceMice, Inbred C57BLProdrugsPurinergic P2Y Receptor AgonistsPurinergic P2Y Receptor AntagonistsReceptor, Adenosine A1Receptor, Adenosine A3Receptors, Purinergic P2Y12-iodo-N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphateAdenosine A1 Receptor AgonistsAdenosine A3 Receptor AgonistsAdenosine DiphosphateDeoxyadenine NucleotidesN(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate(N)-methanocarba-2MeSADPProdrugsPurinergic P2Y Receptor AgonistsPurinergic P2Y Receptor AntagonistsReceptor, Adenosine A1Receptor, Adenosine A3Receptors, Purinergic P2Y1A1 receptorA3 receptorAdenosineEctonucleotidaseP2Y1 receptorProdrug

Identifiers

PMID33129204
PMCPMC7855190
OpenAlexW3095017572

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.