Evidence map›Paper›PMID 33130550›Full record

SynthesisEuropean journal of cancer (Oxford, England : 1990)2020

A systematic review and meta-analysis: the effect of active cancer treatment on severity of COVID-19.

Emre Yekedüz, Güngör Utkan, Yüksel Ürün

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of cancer (Oxford, England : 1990), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 12 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 12 syntheses or guidelines pooled it, 119 citations in OpenAlex.

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  5. Intracranial drainage versus extracranial shunt in the treatment of intracranial arachnoid cysts: a meta-analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022
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  10. Seroconversion rate after vaccination against COVID-19 in patients with cancer-a systematic review.Annals of oncology : official journal of the European Society for Medical Oncology · 2022
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Emre YekedüzDepartment of Medical Oncology, Ankara University, Ankara, Turkey; Ankara University Cancer Research Institute, Ankara, Turkey. Electronic address: emreyekeduz@gmail.com.
Güngör UtkanDepartment of Medical Oncology, Ankara University, Ankara, Turkey; Ankara University Cancer Research Institute, Ankara, Turkey.
Yüksel ÜrünDepartment of Medical Oncology, Ankara University, Ankara, Turkey; Ankara University Cancer Research Institute, Ankara, Turkey.
Ankara University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe COVID-19 pandemic hit all over the world, and cancer patients are more vulnerable for COVID-19. The mortality rate may increase up to 25% in solid malignancies. In parallel to increased mortality rates among cancer patients, safety concerns regarding cancer treatment has increased over time. However, there were contradictory results for the cancer treatment during pandemic. In this study, we assessed the effect of cancer treatment on the severity of COVID-19.

methodsThe MEDLINE database was searched on September 01, 2020. Primary end-points were severe disease and death in the cancer patients treated within the last 30 days before COVID-19 diagnosis. Quality of included studies was assessed by Newcastle-Ottawa scale. The generic inverse-variance method was used to calculate odds ratios (ORs) for each outcome.

resultsSixteen studies were included for this meta-analysis. Chemotherapy within the last thirty days before COVID-19 diagnosis increased the risk of death in cancer patients after adjusting for confounding variables (OR: 1.85; 95% confidence interval: 1.26-2.71). However, severe COVID-19 risk did not increase. Furthermore, targeted therapies, immunotherapy, surgery and radiotherapy did not increase the severe disease and death risk in cancer patients with COVID-19.

conclusionChemotherapy increased the risk of death from COVID-19 in cancer patients. However, there was no safety concern for immunotherapy, targeted therapies, surgery and radiotherapy.

Indexed as

Antineoplastic AgentsCOVID-19FemaleHumansMaleNeoplasmsPandemicsSARS-CoV-2TurkeyAntineoplastic AgentsCancer treatmentChemotherapyCOVID-19ImmunotherapySARS-CoV-2Targeted therapy

Identifiers

PMID33130550
PMCPMC7538140
OpenAlexW3091376205

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.