Evidence map›Paper›PMID 33134134›Full record

ArticleJournal of traditional and complementary medicine2020

Chrysin mitigated obesity by regulating energy intake and expenditure in rats.

Sarayu A Pai, Elvis Adrian Martis, Renuka P Munshi, Malvika S Gursahani, Snehal N Mestry, Archana R Juvekar

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional and complementary medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. New Mediators in the Crosstalk between Different Adipose Tissues.International journal of molecular sciences · 2024
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sarayu A PaiPharmacology Research Laboratory 1, Dept. of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N.P. Marg, Matunga, Mumbai, 400 019, India.
Elvis Adrian MartisMolecular Simulations Group, Dept. of Pharmaceutical Chemistry, Bombay College of Pharmacy, Kalina, Santa Cruz (E), Mumbai, 400 098, India.
Renuka P MunshiDept. of Clinical Pharmacology, T. N. Medical College and BYL Nair Charitable Hospital, Dr A. L. Nair Road, Mumbai Central, Mumbai, 400 008, India.
Malvika S GursahaniPharmacology Research Laboratory 1, Dept. of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N.P. Marg, Matunga, Mumbai, 400 019, India.
Snehal N MestryPharmacology Research Laboratory 1, Dept. of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N.P. Marg, Matunga, Mumbai, 400 019, India.
Archana R JuvekarPharmacology Research Laboratory 1, Dept. of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N.P. Marg, Matunga, Mumbai, 400 019, India.
Institute of Chemical Technology · INBombay College of Pharmacy · INTopiwala National Medical College & BYL Nair Charitable Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimChrysin is a flavonoid found in plant extracts from EXPERIMENTAL PROCEDURE: The pancreatic lipase (PL) inhibitory potential of chrysin was determined by preliminary

resultsChrysin showed good affinity to PL with competitive type of inhibition. It significantly reduced serum triglycerides in OFTT. Chrysin also significantly reduced acute feed intake and sucrose preference in rats. Chrysin significantly decreased the body weight, BMI, AC/TC ratio, adiposity index, calorie intake while it significantly increased the fecal cholesterol and locomotor activity of the rats. Chrysin was found to reduce the size of the adipocytes when compared to the HFD control group.

conclusionThus, chrysin exerted anti-obesity effect by inhibiting PL, reducing sucrose preference, reducing calorie intake and increasing the locomotor activity of rats.

Indexed as

AC/TC, ratio-abdominal circumference to thoracic circumference ratioAdipose tissueAUC, area under the curveBMI, body mass indexC100, chrysin 100 mg/kg p.o. body weightC25, chrysin 25 mg/kg p.o. body weightC50, chrysin 50 mg/kg p.o. body weightGLP, 1-glucagon like peptide 1HFD, high fructose dietLocomotionNC, normal controlOFTT, oral fat tolerance testOrli, orlistatPancreatic lipasePL, pancreatic lipasep-NPP, p-nitrophenyl palmitateSEM, standard error of meanSucrose preferenceTG, triglyceridesVC, vehicle control

Identifiers

PMID33134134
PMCPMC7588347
OpenAlexW2971639169

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.