Evidence map›Paper›PMID 33135183›Full record

ArticleThe Journal of comparative neurology2021

Identification of retinal ganglion cell types and brain nuclei expressing the transcription factor Brn3c/Pou4f3 using a Cre recombinase knock-in allele.

Nadia Parmhans, Anne Drury Fuller, Eileen Nguyen, Katherine Chuang, David Swygart, Sophia Rose Wienbar, Tyger Lin, Zbynek Kozmik, Lijin Dong, Gregory William Schwartz and 1 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of comparative neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. The RBPMSiScience · 2023
    Article
  3. InducibleCells · 2023
    Article
  4. Article
  5. Review
  6. Layer 5 of cortex innervates the thalamic reticular nucleus in mice.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Nadia ParmhansRetinal Circuit Development and Genetics Unit, Neurobiology-Neurodegeneration and Repair Laboratory, National Eye Institute, NIH, Bethesda, Maryland, USA.
Anne Drury FullerRetinal Circuit Development and Genetics Unit, Neurobiology-Neurodegeneration and Repair Laboratory, National Eye Institute, NIH, Bethesda, Maryland, USA.
Eileen NguyenRetinal Circuit Development and Genetics Unit, Neurobiology-Neurodegeneration and Repair Laboratory, National Eye Institute, NIH, Bethesda, Maryland, USA.
Katherine ChuangRetinal Circuit Development and Genetics Unit, Neurobiology-Neurodegeneration and Repair Laboratory, National Eye Institute, NIH, Bethesda, Maryland, USA.
David SwygartDepartments of Ophthalmology and Physiology Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
Sophia Rose WienbarDepartments of Ophthalmology and Physiology Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
Tyger LinRetinal Circuit Development and Genetics Unit, Neurobiology-Neurodegeneration and Repair Laboratory, National Eye Institute, NIH, Bethesda, Maryland, USA.
Zbynek KozmikInstitute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Lijin DongGenetic Engineering Facility, National Eye Institute, NIH, Bethesda, Maryland, USA.
Gregory William SchwartzDepartments of Ophthalmology and Physiology Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
Tudor Constantin BadeaRetinal Circuit Development and Genetics Unit, Neurobiology-Neurodegeneration and Repair Laboratory, National Eye Institute, NIH, Bethesda, Maryland, USA.ORCID 0000-0003-3086-6713
National Eye Institute · USNorthwestern University · USCzech Academy of Sciences · CZ

Funding

NEI Genetic Engineering CoreZICEY000458 · NEI · NATIONAL EYE INSTITUTE · PI DONG, LIJIN · 2009 to 2025
$22.6M
Retinal Circuit Development & GeneticsZIAEY000504 · NEI · NATIONAL EYE INSTITUTE · PI BADEA, TUDOR · 2011 to 2021
$15.6M
Novel circuit mapping strategies to reverse engineer the retinaDP2EY026770 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SCHWARTZ, GREGORY WILLIAM · 2015 to 2015
$2.3M
Functional Divergence at the Mouse Type 6 Bipolar Cell TerminalF31EY030344 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SWYGART, DAVID ISAIAH · 2019 to 2021
$137k
Intrinsic electrical properties shape feature selectivity in a novel retinal ganglion cellF31EY030737 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WIENBAR, SOPHIA ROSE · 2019 to 2021
$130k
Intramural NIH HHS ZIA EY000504NEI NIH HHS DP2 EY026770NEI NIH HHS F31 EY030344NEI NIH HHS F31 EY030737
6 · The paper itself

Abstract

Members of the POU4F/Brn3 transcription factor family have an established role in the development of retinal ganglion cell (RGCs) types, the main transducers of visual information from the mammalian eye to the brain. Our previous work using sparse random recombination of a conditional knock-in reporter allele expressing alkaline phosphatase (AP) and intersectional genetics had identified three types of Brn3c positive (Brn3c

Indexed as

AllelesAnimalsBrainGene Knock-In TechniquesHomeodomain ProteinsIntegrasesMiceRetinal Ganglion CellsTranscription Factor Brn-3CVisual PathwaysCre recombinaseHomeodomain ProteinsIntegrasesPou4f3 protein, mouseTranscription Factor Brn-3CBrn3cCre recombinasedeep mesencephalic nucleusperiaqueductal grayPou4f3retinal ganglion cellssuperior colliculusthalamic reticular nucleustranscription factor

Identifiers

PMID33135183
PMCPMC8009822
OpenAlexW3095693204

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.