Evidence map›Paper›PMID 33144396›Full record

ArticleDevelopment (Cambridge, England)2020

Negative feedback by conserved kinases patterns the degradation of

Claire C de la Cova, Robert Townley, Iva Greenwald

Open access · greenAbstract read
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. The mTOR pathway controls phosphorylation of BRAF at T401.Cell communication and signaling : CCS · 2024
    Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Claire C de la CovaDepartment of Biological Sciences, Columbia University, New York, NY 10027, USA.ORCID 0000-0001-8719-6883
Robert TownleyDepartment of Biological Sciences, Columbia University, New York, NY 10027, USA.
Iva GreenwaldDepartment of Biological Sciences, Columbia University, New York, NY 10027, USA.
Columbia University · USUniversity of Wisconsin–Milwaukee · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Regulatory Circuitry and Mechanisms Controlling Cell Fate in C. elegansR35GM131746 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Iva S Greenwald · 2019 to 2026
$5.0M
New modes and mechanisms of negative regulation of LIN-12/Notch in C. elegansR01GM114140 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GREENWALD, IVA S · 2015 to 2018
$1.4M
NIGMS NIH HHS R01 GM114140NIGMS NIH HHS R35 GM131746NIH HHS P40 OD010440
6 · The paper itself

Abstract

Activation of a canonical EGFR-Ras-Raf-ERK cascade initiates patterning of multipotent vulval precursor cells (VPCs) of

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell Cycle ProteinsCell DifferentiationFeedback, PhysiologicalFemaleGene Expression Regulation, DevelopmentalGlycogen Synthase Kinase 3PhosphotransferasesProteolysisraf KinasesSignal TransductionUbiquitin-Protein LigasesVulvaCaenorhabditis elegans ProteinsCell Cycle ProteinsGlycogen Synthase Kinase 3lin-45 protein, C elegansPhosphotransferasesraf KinasesSEL-10 protein, C elegansUbiquitin-Protein LigasesCdc4 phosphodegronLIN-45/BRAFNegative feedbackProtein degradationRaf-MEK-ERKSEL-10/FBXW7

Identifiers

PMID33144396
PMCPMC7774884
OpenAlexW3097329323

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.