Evidence map›Paper›PMID 33146244›Full record

ArticleMemorias do Instituto Oswaldo Cruz2020

CD14 genotype and functional dichotomy of CD14+ and CD14- cells are associated with activated immune response and development of Chagas dilated cardiomyopathy.

Germano Carneiro Costa, Manoel Otávio da Costa Rocha, Paulo Eduardo Alencar de Souza, Diego Felipe Sa Melo, Paula Rocha Moreira, Kenneth John Gollob, Maria do Carmo Pereira Nunes, Walderez Ornelas Dutra

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In one paragraph

Article in Memorias do Instituto Oswaldo Cruz, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Germano Carneiro CostaUniversidade Federal de Viçosa, Florestal, MG, Brasil.ORCID http://orcid.org/0000-0003-3711-5840
Manoel Otávio da Costa RochaUniversidade Federal de Minas Gerais, Faculdade de Medicina, Programa de Pós-Graduação em Infectologia e Medicina Tropical, Belo Horizonte, MG, Brasil.
Paulo Eduardo Alencar de SouzaPontifícia Universidade Católica de Minas Gerais, Faculdade de Odontologia, Belo Horizonte, MG, Brasil.
Diego Felipe Sa MeloUniversidade Federal de Minas Gerais, Departamento de Morfologia, Laboratório de Biologia das Interações Celulares, Belo Horizonte, MG, Brasil.
Paula Rocha MoreiraUniversidade Federal de Minas Gerais, Departamento de Morfologia, Laboratório de Biologia das Interações Celulares, Belo Horizonte, MG, Brasil.
Kenneth John GollobAC Camargo Cancer Center, São Paulo, SP, Brasil.
Maria do Carmo Pereira NunesUniversidade Federal de Minas Gerais, Faculdade de Medicina, Programa de Pós-Graduação em Infectologia e Medicina Tropical, Belo Horizonte, MG, Brasil.
Walderez Ornelas DutraUniversidade Federal de Minas Gerais, Departamento de Morfologia, Laboratório de Biologia das Interações Celulares, Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais · BRAC Camargo Hospital · BRPontifícia Universidade Católica de Minas Gerais · BRUniversidade Federal de Viçosa · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to investigate the association of CD14 -260C/T (rs2569190) polymorphism and Chagas cardiomyopathy and the functional characteristics of CD14+ and CD14- monocytes upon infection with Trypanosoma cruzi. We observed an association between the T- genotype (absence of allele -260T) related to low CD14 expression and the dilated cardiomyopathy type of Chagas disease. Furthermore, we observed that CD14- monocytes showed a more activated profile upon in vitro infection with T. cruzi than CD14+ monocytes. Our findings suggest that T- genotype is associated with susceptibility to develop Chagas dilated cardiomyopathy, likely linked to the T. cruzi-induced inflammatory profile of CD14- monocytes.

Indexed as

Cardiomyopathy, DilatedChagas CardiomyopathyChagas DiseaseGenotypeHeart FailureHumansLipopolysaccharide ReceptorsTrypanosoma cruziVentricular Dysfunction, LeftCD14 protein, humanLipopolysaccharide Receptors

Identifiers

PMID33146244
PMCPMC7592494
OpenAlexW3097970441

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.