Evidence map›Paper›PMID 33147119›Full record

ArticleMolecular imaging

[

Thuy T Tran, Jean-Dominique Gallezot, Lucia B Jilaveanu, Christopher Zito, Gabriela Turcu, Keunpoong Lim, Nabeel Nabulsi, Henry Huang, Anita Huttner, Harriet M Kluger and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecular imaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Microglia and metastases to the central nervous system: victim, ravager, or something else?Journal of experimental & clinical cancer research : CR · 2022
    Review
  5. Review
  6. Emerging Studies of Melanoma Brain Metastasis.Current oncology reports · 2022
    Review
  7. Review
  8. Review
  9. Review
  10. Have (R)-[European journal of nuclear medicine and molecular imaging · 2021
    Article
  11. Novel Tracers and Radionuclides in PET Imaging.Radiologic clinics of North America · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Thuy T TranYale School of Medicine and Yale Cancer Center, 12228Yale University, New Haven, CT, USA.ORCID 0000-0002-6244-7575
Jean-Dominique GallezotDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, 12228Yale University, New Haven, CT, USA.
Lucia B JilaveanuYale School of Medicine and Yale Cancer Center, 12228Yale University, New Haven, CT, USA.
Christopher ZitoDepartment of Biology, School of Health and Natural Sciences, 8515University of Saint Joseph, West Hartford, CT, USA.
Gabriela TurcuYale School of Medicine and Yale Cancer Center, 12228Yale University, New Haven, CT, USA.
Keunpoong LimDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, 12228Yale University, New Haven, CT, USA.
Nabeel NabulsiDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, 12228Yale University, New Haven, CT, USA.
Henry HuangDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, 12228Yale University, New Haven, CT, USA.
Anita HuttnerDepartment of Pathology, Yale School of Medicine, 12228Yale University, New Haven, CT, USA.
Harriet M KlugerYale School of Medicine and Yale Cancer Center, 12228Yale University, New Haven, CT, USA.
Veronica L ChiangYale School of Medicine and Yale Cancer Center, 12228Yale University, New Haven, CT, USA.
Richard CarsonDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, 12228Yale University, New Haven, CT, USA.
Yale University · USYale Cancer Center · USUniversity of Saint Joseph · US

Funding

Yale SPORE in Skin CancerP50CA121974 · NCI · YALE UNIVERSITY · PI MARCUS W BOSENBERG, Harriet M. Kluger · 2006 to 2026
$43.9M
YALE CANCER CENTER CALABRESI IMMUNO-ONCOLOGY TRAINING PROGRAMK12CA215110 · NCI · YALE UNIVERSITY · PI Harriet M. Kluger · 2018 to 2026
$6.1M
(8) Mechanisms of autoimmune endocrine diseases in patients receiving checkpoint inhibitorsR01CA227473 · NCI · YALE UNIVERSITY · PI HEROLD, KEVAN C, KLUGER, HARRIET M. · 2018 to 2022
$3.2M
Yale Cancer Center Advanced Training Program for Physician-Scientists (YCC-ATPP)T32CA233414 · NCI · YALE UNIVERSITY · PI Eric P. Winer · 2019 to 2026
$3.2M
Inherent tropism and/or immune modulation in melanoma brain metastasisR01CA204002 · NCI · YALE UNIVERSITY · PI JILAVEANU, LUCIA BEATRICE · 2017 to 2021
$1.9M
Models to Predict Prognosis and Benefit from Adjuvant Therapy in Renal Cell CarciR01CA158167 · NCI · YALE UNIVERSITY · PI KLUGER, HARRIET M. · 2011 to 2015
$1.8M
A research and training program for junior clinicians in treating metastatic melaK24CA172123 · NCI · YALE UNIVERSITY · PI KLUGER, HARRIET M. · 2013 to 2017
$780k
NCI NIH HHS K12 CA215110NCI NIH HHS K24 CA172123NCI NIH HHS P50 CA121974NCI NIH HHS R01 CA158167NCI NIH HHS R01 CA204002NCI NIH HHS R01 CA227473NCI NIH HHS T32 CA233414
6 · The paper itself

Abstract

purposeAs stereotactic radiosurgery (SRS) and immunotherapy are increasingly used to treat brain metastases, incidence of radiation necrosis (RN) is consequently rising. Differentiating tumor regrowth (TR) from RN is vital in management but difficult to assess using MRI. We hypothesized that tumor methionine levels would be elevated given increased metabolism and high amino acid uptake, whereas RN would increase inflammation marked by upregulated translocator protein (PBR-TSPO), which can be quantified with specific PET tracers. PROCEDURES: We performed a feasibility study to prospectively evaluate [

resultsSequential imaging with dual tracers was well-tolerated. [

conclusionSequential use of PET tracers is safe and effective. [

Indexed as

Brain NeoplasmsRadiation InjuriesHumansMethionineNecrosisNeoplasm Recurrence, LocalPositron-Emission TomographyReceptors, GABAMethionineReceptors, GABATSPO protein, human[11C]methionine[11C]PBR28brain metastasisPETradiation necrosis

Identifiers

PMID33147119
PMCPMC7649862
OpenAlexW3096950987

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.