Evidence map›Paper›PMID 33148439›Full record

Observational studyBrain, behavior, and immunity2021

Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study.

Jingqi Zhou, Chang Liu, Yitang Sun, Weishan Huang, Kaixiong Ye

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Brain, behavior, and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 5 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 5 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Pooled it
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  3. Changes in cognitive functioning after COVID-19: A systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022
    Pooled it
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  5. Dementia is an age-independent risk factor for severity and death in COVID-19 inpatients.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
    Pooled it
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  19. Post-acute COVID-19 syndrome.European respiratory review : an official journal of the European Respiratory Society · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Jingqi ZhouDepartment of Genetics, Franklin College of Arts and Sciences, University of Georgia, Athens, GA, USA; School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
Chang LiuDepartment of Genetics, Franklin College of Arts and Sciences, University of Georgia, Athens, GA, USA; College of Life Sciences, Wuhan University, Wuhan, PR China.
Yitang SunDepartment of Genetics, Franklin College of Arts and Sciences, University of Georgia, Athens, GA, USA.
Weishan HuangDepartment of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Kaixiong YeDepartment of Genetics, Franklin College of Arts and Sciences, University of Georgia, Athens, GA, USA; Institute of Bioinformatics, University of Georgia, Athens, GA, USA. Electronic address: Kaixiong.Ye@uga.edu.
Franklin College · USUniversity of Georgia · USCornell University · US

Funding

Medical Research Council MC_PC_17228Medical Research Council MC_QA137853
6 · The paper itself

Abstract

introductionOur understanding of risk factors for COVID‑19, including pre-existing medical conditions and genetic variations, is limited. To what extent the pre-existing clinical condition and genetic background have implications for COVID-19 still needs to be explored.

methodsOur study included 389,620 participants of European descent from the UK Biobank, of whom 3,884 received the COVID-19 test and 1,091 were tested positive for COVID-19. We examined the association of COVID-19 status with an extensive list of 974 medical conditions and 30 blood biomarkers. Additionally, we tested the association of genetic variants in two key genes related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2), with COVID-19 or any other phenotypes.

resultsThe most significant risk factors for COVID-19 include Alzheimer's disease (OR = 2.29, 95% CI: 1.25-4.16), dementia (OR = 2.16, 95% CI: 1.36-3.42), and the overall category of delirium, dementia, amnestic and other cognitive disorders (OR = 1.90, 95% CI: 1.24-2.90). Evidence suggesting associations of genetic variants in SARS-CoV-2 infection-related genes with COVID-19 (rs7282236, OR = 1.33, 95% CI: 1.14-1.54, p = 2.31 × 10

conclusionsOur unbiased and extensive search identified pre-existing Alzheimer's disease and dementia as top risk factors for hospital admission due to COVID-19, highlighting the importance of providing special protective care for patients with cognitive disorders during this pandemic. We also obtained evidence suggesting a direct association of genetic variants with COVID-19.

Indexed as

AdultAgedAngiotensin-Converting Enzyme 2BiomarkersCognitionCognitive DysfunctionCohort StudiesCOVID-19FemaleHospitalizationHumansMaleMiddle AgedPandemicsRisk FactorsSARS-CoV-2Angiotensin-Converting Enzyme 2BiomarkersSerine EndopeptidasesTMPRSS2 protein, humanAlzheimer's diseaseCognitive disordersCOVID-19DementiaPre-existing conditionsRisk factors

Identifiers

PMID33148439
PMCPMC7584518
OpenAlexW3094604469

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.