Evidence mapPaperPMID 33149596Full record

Observational studyVascular health and risk management2020

Risk of Atrial Fibrillation, Ischemic Stroke and Cognitive Impairment: Study of a Population Cohort ≥65 Years of Age.

Jose-Luis Clua-Espuny, Eulalia Muria-Subirats, Juan Ballesta-Ors, Blanca Lorman-Carbo, Josep Clua-Queralt, Elena Palà, Iñigo Lechuga-Duran, Delicia Gentille-Lorente, Alejandro Bustamante, Miguel Ángel Muñoz and 2 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Vascular health and risk management, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03188484 (Stepwise High Risk Individuals Screening for Atrial Fibrillation Using Sequential Clinical-electro-biological Register), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03188484 completednot on this map

Stepwise High Risk Individuals Screening for Atrial Fibrillation Using Sequential Clinical-electro-biological Register: the AFRICAT Study (Atrial Fibrillation Research In CATalonia)

Typeobservational_patient_registrySponsorFundacio d'Investigacio en Atencio Primaria Jordi Gol i GurinaRan2016 to 2019Enrolled492ConditionsArrhythmia Atrial, Atrial Fibrillation, Hypertension, Diabetes Mellitus
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jose-Luis Clua-EspunyEAP Tortosa 1-Est, Institut Català Salut, Servei Atenció Primària, UUDD Terres De l'Ebre. Universidad Rovira I Virgili, Programa Doctorat, Tortosa, Spain.ORCID 0000-0002-6508-5741
Eulalia Muria-SubiratsEAP Tortosa 1-Est, Institut Català Salut, SAP Terres De l'Ebre, España Universidad Rovira I Virgili. Programa Doctorat, Tortosa, Tarragona, Spain.ORCID 0000-0002-0119-9387
Juan Ballesta-OrsEAP Tortosa 1-Est, Institut Català Salut, SAP Terres De l'Ebre, Universidad Rovira I Virgili. Programa Doctorat. Tortosa, Tarragona, Spain.ORCID 0000-0002-0971-0936
Blanca Lorman-CarboEAP Tortosa 1-Est, Institut Català Salut, SAP Terres De l'Ebre, España Universidad Rovira I Virgili. Programa Doctorat. Tortosa, Tarragona, Spain.
Josep Clua-QueraltUniversitat De Lleida, Lérida, Spain.
Elena PalàNeurovascular Research Laboratory, Vall d'Hebron Institute of Research (VHIR)-Universitat Autónoma De Barcelona, Barcelona, Spain.
Iñigo Lechuga-DuranServicio Cardiología, Hospital Virgen De La Cinta, Institut Català Salut Tortosa, Tarragona, Spain.
Delicia Gentille-LorenteServicio Cardiología, Hospital Virgen De La Cinta, Institut Català Salut Tortosa, Tarragona, Spain.
Alejandro BustamanteDepartment of Neurology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Miguel Ángel MuñozInstitut d'Investigació En Atenció Primària IDIAP Jordi Gol, Unitat De Suport a La Recerca De Barcelona, Barcelona, Spain.
Joan MontanerNeurovascular Research Laboratory, Vall d'Hebron Institute of Research (VHIR)-Universitat Autónoma De Barcelona, Barcelona, Spain.
AFRICAT Research Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate a model for calculating the risk of AF and its relationship with the incidence of ischemic stroke and prevalence of cognitive decline. MATERIALS AND

methodsIt was a multicenter, observational, retrospective, community-based study of a cohort of general population ≥6ct 35 years, between 01/01/2016 and 31/12/2018. Setting: Primary Care. Participants: 46,706 people ≥65 years with an active medical history in any of the primary care teams of the territory, information accessible through shared history and without previous known AF. Interventions: The model to stratify the risk of AF (PI) has been previously published and included the variables sex, age, mean heart rate, mean weight and CHA2DS2VASc score. Main measurements: For each risk group, the incidence density/1000 person/years of AF and stroke, number of cases required to detect a new AF, the prevalence of cognitive decline, Kendall correlation, and ROC curve were calculated.

resultsThe prognostic index was obtained in 37,731 cases (80.8%) from lowest (Q1) to highest risk (Q4). A total of 1244 new AFs and 234 stroke episodes were diagnosed. Q3-4 included 53.8% of all AF and 69.5% of strokes in men; 84.2% of all AF and 85.4% of strokes in women; and 77.4% of cases of cognitive impairment. There was a significant linear correlation between the risk-AF score and the Rankin score (p < 0.001), the Pfeiffer score (p < 0.001), but not NIHSS score (p 0.150). The overall NNS was 1/19.

conclusionRisk stratification allows identifying high-risk individuals in whom to intervene on modifiable risk factors, prioritizing the diagnosis of AF and investigating cognitive status.

Indexed as

CognitionAgedAged, 80 and overAtrial FibrillationBrain IschemiaCognitive DysfunctionFemaleHumansIncidenceMalePrevalencePrognosisRetrospective StudiesRisk AssessmentRisk FactorsSex Factorsatrial arrhythmiacerebrovascular diseasecognitive declinesilent strokevascular risk score

Identifiers

PMID33149596
PMCPMC7605602

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.