Trial reportThe Journal of clinical endocrinology and metabolism2021
Bone Mineral Density and Turnover After Sleeve Gastrectomy and Gastric Bypass: A Randomized Controlled Trial (Oseberg).
Trial report in The Journal of clinical endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01778738 (Glycaemia, Insulin Secretion and Action in Morbidly Obese Subjects With Type 2 Diabetes After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass), which is not on this map. Cited by 35 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Glycaemia, Insulin Secretion and Action in Morbidly Obese Subjects With Type 2 Diabetes After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass: A Randomised Single Centre Study
Who cites it
35 citing papers in PubMed, 6 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Effects of Incretin-Based Therapies, Diet and Exercise Interventions, and Bariatric Surgery on Fat-Free Mass in Adults With Overweight or Obesity: A Systematic Review and Meta-Analysis.Diabetes, obesity & metabolism · 2026Pooled it
- Metabolic/Bariatric Surgery is Safe and Effective in People with Obesity, Type 2 Diabetes Mellitus and Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Obesity surgery · 2024Pooled it
- Randomized controlled trials comparing gastric bypass, gastric band, and sleeve gastrectomy: A systematic review examining validity and applicability to wider clinical practice.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2024Pooled it
- Changes in Bone Turnover Markers after Roux-en-Y Gastric Bypass Versus Sleeve Gastrectomy: a Systematic Review and Meta-Analysis.Obesity surgery · 2023Pooled it
- Fracture risk following bariatric surgery: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Pooled it
- EAES rapid guideline: systematic review, network meta-analysis, CINeMA and GRADE assessment, and European consensus on bariatric surgery-extension 2022.Surgical endoscopy · 2022Guideline
- Weight loss independent outcomes in type 2 diabetes mellitus and other metabolic comorbidities after Roux-en-Y gastric bypass and sleeve gastrectomy.International journal of obesity (2005) · 2026Article
- Weight loss induced bone loss: mechanism of action and clinical implications.Bone research · 2025Review
- Are we giving too much weight to lean mass loss?Molecular metabolism · 2025Review
- Article
- One Year Changes in Body Composition and Musculoskeletal Health Following Metabolic/Bariatric Surgery.The Journal of clinical endocrinology and metabolism · 2025Article
- Vertical sleeve gastrectomy and semaglutide have distinct effects on skeletal health and heart function in obese male mice.American journal of physiology. Endocrinology and metabolism · 2025Article
- Comparing Mannitol and Hypertonic Dextrose Injections for Knee Osteoarthritis Pain and Function: A Randomised Trial.Mediterranean journal of rheumatology · 2025Article
- The Short-Term Impact of Sleeve Gastrectomy on Bone Health.Mediterranean journal of rheumatology · 2025Article
- Load-to-strength ratio as an estimate of wrist facture after gastric bypass vs gastric banding.JBMR plus · 2025Article
- Management of Adverse Skeletal Effects Following Bariatric Surgery Procedures in People Living with Obesity.Current osteoporosis reports · 2025Review
- Comparative effectiveness of metabolic and bariatric surgeries: a network meta-analysis.International journal of obesity (2005) · 2025Review
- DXA evaluation of bone fragility 2 years after bariatric surgery in patients with obesity.Bone reports · 2024Article
- Changes in bone turnover markers 6-12 months after bariatric surgery.Scientific reports · 2024Article
- Long-Term Differential Effects of Gastric Bypass and Sleeve Gastrectomy on Bone Mineral Density.Journal of the Endocrine Society · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextBariatric surgery, particularly Roux-en-Y gastric bypass (RYGB), is associated with an increased risk of osteoporotic fractures. It is unknown whether RYGB or sleeve gastrectomy (SG) have different effects on bone health.
objectiveTo compare changes in bone mineral density and markers of bone turnover 1 year after SG and RYGB. DESIGN, SETTING, PATIENTS, AND
interventionsRandomized, triple-blind, single-center trial at a tertiary care center in Norway. The primary outcome was diabetes remission. Patients with severe obesity and type 2 diabetes were randomized and allocated (1:1) to SG or RYGB.
main outcome measuresChanges in areal bone mineral density (aBMD) and bone turnover markers.
resultsFemoral neck, total hip, and lumbar spine aBMD, but not total body aBMD, decreased significantly more after RYGB (n = 44) than after SG (n = 48) (mean [95% confidence interval] between group differences -2.8% [-4.7 to -0.8], -3.0% [-5.0 to -0.9], -4.2% [-6.4 to -2.1], and -0.5% [-1.6 to 0.6], respectively). The increase in procollagen type 1 N-terminal propeptide (P1NP) and C-telopeptide of type I collagen (CTX-1) were approximately 100% higher after RYGB than after SG (between group difference at 1 year, both P < 0.001). The changes in femoral neck, total hip, and lumbar spine aBMDs and the changes in P1NP and CTX-1 were independently associated with the surgical procedure (all P < 0.05) and not weight change.
conclusionsRoux-en-Y gastric bypass was associated with a greater reduction in aBMD and a greater increase in bone turnover markers compared with SG. This finding could suggest greater skeletal fragility after RYGB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.