ReviewInternational journal of molecular sciences2020
Search for Reliable Circulating Biomarkers to Predict Carotid Plaque Vulnerability.
Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05300997 (Translational Immunodiagnostics in Suspected Stroke), which is not on this map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Translational Immunodiagnostics in Suspected Stroke (TrImS): A Two-centre, Pragmatic, Prospective, Observational Study
Who cites it
32 citing papers in PubMed, 51 citations in OpenAlex.
- Consensus machine learning identifies cell death gene signature for carotid artery stenosis diagnosis.iScience · 2026Article
- Serum PTX3 Levels Correlate with Fibrous Cap Discontinuity and Focal Inflammation in Carotid Vulnerable Plaque: A High-Resolution Magnetic Resonance Vessel Wall Imaging Study.Journal of clinical medicine · 2026Article
- Construction of a prediction model for large-artery atherosclerosis ischemic stroke based on blood biomarkers and ultrasonic imaging.BMC neurology · 2026Article
- Article
- Association between non-traditional lipid parameters and futile recanalization in patients with acute ischemic stroke undergoing mechanical thrombectomy.European journal of medical research · 2025Article
- The Association of Histological Signs of Plaque Instability with Low eGFR, Higher Neutrophil-to-Lymphocyte Ratio, and Lower Serum MCP-1 Levels in Carotid Endarterectomy Patients-A Single-Center, Prospective Cohort Study.Life (Basel, Switzerland) · 2025Article
- Association of matrix metalloproteinases and adhesive molecules with important aspects of carotid artery stenosis.Journal of medical biochemistry · 2025Article
- Construction of vulnerable plaque prediction model based on multimodal vascular ultrasound parameters and clinical risk factors.Scientific reports · 2024Article
- Identification and experimental validation of KMO as a critical immune-associated mitochondrial gene in unstable atherosclerotic plaque.Journal of translational medicine · 2024Article
- Molecular Pathways of Vulnerable Carotid Plaques at Risk of Ischemic Stroke: A Narrative Review.International journal of molecular sciences · 2024Review
- Serum from Stroke Patients with High-Grade Carotid Stenosis Promotes Cyclooxygenase-Dependent Endothelial Dysfunction in Non-ischemic Mice Carotid Arteries.Translational stroke research · 2024Article
- NSUN6 and HTR7 disturbed the stability of carotid atherosclerotic plaques by regulating the immune responses of macrophages.Open medicine (Warsaw, Poland) · 2024Article
- Searching for Atherosclerosis Biomarkers by Proteomics: A Focus on Lesion Pathogenesis and Vulnerability.International journal of molecular sciences · 2023Review
- Novel Biomarkers and Imaging Indices for the "Vulnerable Patient" with Carotid Stenosis: A Single-Center Study.Biomolecules · 2023Article
- Novel Therapeutic Approaches to Prevent Atherothrombotic Ischemic Stroke in Patients with Carotid Atherosclerosis.International journal of molecular sciences · 2023Review
- Article
- Oxidative Stress as a Reliable Biomarker of Carotid Plaque Instability: A Pilot Study.Antioxidants (Basel, Switzerland) · 2023Article
- Carotid Artery Disease in the Era of Biomarkers: A Pilot Study.Diagnostics (Basel, Switzerland) · 2023Article
- Exosomal circSCMH1/miR-874 ratio in serum to predict carotid and coronary plaque stability.Frontiers in cardiovascular medicine · 2023Article
- microRNAs Associated with Carotid Plaque Development and Vulnerability: The Clinician's Perspective.International journal of molecular sciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Atherosclerosis is responsible for 20% of ischemic strokes, and the plaques from the internal carotid artery the most frequently involved. Lipoproteins play a key role in carotid atherosclerosis since lipid accumulation contributes to plaque progression and chronic inflammation, both factors leading to plaque vulnerability. Carotid revascularization to prevent future vascular events is reasonable in some patients with high-grade carotid stenosis. However, the degree of stenosis alone is not sufficient to decide upon the best clinical management in some situations. In this context, it is essential to further characterize plaque vulnerability, according to specific characteristics (lipid-rich core, fibrous cap thinning, intraplaque hemorrhage). Although these features can be partly detected by imaging techniques, identifying carotid plaque vulnerability is still challenging. Therefore, the study of circulating biomarkers could provide adjunctive criteria to predict the risk of atherothrombotic stroke. In this regard, several molecules have been found altered, but reliable biomarkers have not been clearly established yet. The current review discusses the concept of vulnerable carotid plaque, and collects existing information about putative circulating biomarkers, being particularly focused on lipid-related and inflammatory molecules.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.