ReviewEye and brain2020
A Review of Neuro-Ophthalmological Manifestations of Human Coronavirus Infection.
Review in Eye and brain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Ocular Surface Disorders in ICU Patients: Evidence-Based Nursing Prevention Strategies.Translational vision science & technology · 2025Pooled it
- SARS-CoV-2 (COVID-19) and audio-vestibular disorders.International journal of immunopathology and pharmacologyPooled it
- A review of neuro-ophthalmic sequelae following COVID-19 infection and vaccination.Frontiers in cellular and infection microbiology · 2024Review
- The Implications of SARS-CoV-2 Infection in a Series of Neuro-Ophthalmological Manifestations-Case Series and Literature Review.Journal of clinical medicine · 2023Article
- Neurovisual Manifestations in Children with Mild COVID-19: An Association to Remember.Neuro-ophthalmology (Aeolus Press) · 2023Article
- Article
- COVID-19 Long-Term Effects: Is There an Impact on the Simple Reaction Time and Alternative-Forced Choice on Recovered Patients?Brain sciences · 2022Article
- Abducense nerve palsy following BBIBP-CorV (Sinopharm) COVID-19 vaccine.Journal francais d'ophtalmologie · 2022Article
- Intratympanic injection of dexamethasone for management of labyrinthitis associated with COVID-19 disease resistant cases.Annals of medicine and surgery (2012) · 2022Article
- Prevalence of symptoms in 1512 COVID-19 patients: have dizziness and vertigo been underestimated thus far?Internal and emergency medicine · 2022Article
- Seven Domains of Persisting Problems after Hospital-treated Covid-19 Indicate a Need For a Multiprofessional Rehabilitation Approach.Journal of rehabilitation medicine · 2022Observational
- COVID-19 and abducens nerve palsy in a 9-year-old girl-case report.Italian journal of pediatrics · 2022Article
- Multiprofessional Neurorehabilitation After COVID-19 Infection Should Include Assessment of Visual Function.Archives of rehabilitation research and clinical translation · 2022Article
- A case of total ophthalmoplegia associated with a COVID-19 infection: case report.Oxford medical case reports · 2022Article
- Bilateral sequential non-arteritic optic neuropathy post-COVID-19.Indian journal of ophthalmology · 2022Article
- Update on overview of ocular manifestations of COVID-19.Frontiers in medicine · 2022Review
- Isolated abducens nerve palsy in a patient with asymptomatic SARS-CoV-2 infection.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2021Review
- Internuclear ophthalmoplegia as a presenting feature in a COVID-19-positive patient.BMJ case reports · 2021Article
- Ophthalmic Screening in Patients with Coronavirus Disease 2019: A Prospective Cohort Study.Journal of clinical medicine · 2021Article
- Opportunities, Challenges and Pitfalls of Using Cannabidiol as an Adjuvant Drug in COVID-19.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHuman coronavirus (HCoVs) are a group of viruses with recognized neurotropic and neuroinvasive capabilities. The reports on the neurological and ocular findings are increasing day after day and several central and peripheral neurological manifestations are already described. However, none specifically describes the neuro-ophthalmological manifestation of HCoVs. This is the first article specifically reviewing neuro-ophthalmological manifestations of HCoVs infection.
methodsPubMed and Google Scholar databases were searched using the keywords: coronaviridae, coronavirus, COVID-19, SARS-CoV-2, SARS-CoV-1, MERS, ocular, ophthalmology, ophthalmological, neuro-ophthalmology, neurological, manifestations. A manual search through the reference lists of relevant articles was also performed. There were no restrictions concerning language or study type and publications not yet printed but available online were considered.
resultsCoronavirus eye involvement is not frequent and includes mostly a typical viral follicular conjunctivitis. Recently, retinal anatomical alterations were described using optic coherence tomography. Neuro-ophthalmological symptoms and signs can appear isolated or associated with neurological syndromes. The manifestations include headache, ocular pain, visual impairment, diplopia, and cranial nerve palsies secondary to Miller Fisher syndrome, Guillain-Barré syndrome, or encephalitis, and nystagmus.
conclusionNeurological and neuro-ophthalmological syndromes, symptoms, and signs should not be neglected and a complete ophthalmological examination of these patients should be performed to fully describe ocular manifestations related to HCoVs. We believe that major ocular and neuro-ophthalmological manifestations reports lack due to safety issues concerning detailed ophthalmological examination; on the other hand, in a large number of cases, the presence of life-threatening coronavirus disease hinders ocular examination and ophthalmologist's visit to the intensive care unit.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.