Evidence map›Paper›PMID 33157128›Full record

ArticleExperimental eye research2020

Quantification of ocular surface microcirculation by computer assisted video microscopy and diffuse reflectance spectroscopy.

Anne Kari Kvernebo, Takuma Miyamoto, Ane Hasle Sporastøyl, Liv Kristin Wikslund, Svein-Erik Måsøy, Liv Drolsum, Morten Carstens Moe, Goran Salerud, Kiyotaka Fukamachi, Knut Kvernebo

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05608798 (Microscopic and Spectroscopic Examination of Skin Microcirculation in Healthy Individuals Using ODI Technology), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05608798 nacompletednot on this mapstarted 2022, after this paper: background citation

Microscopic and Spectroscopic Examination of Skin Microcirculation in Healthy Individuals Using ODI Technology

TypeinterventionalSponsorODI Medical ASRan2022 to 2023Enrolled112ConditionsHealthyArmsODI-Tech medical device
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Anne Kari KverneboDepartment of Ophthalmology, Oslo University Hospital HF, Postboks 4950 Nydalen, 0424, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, P.O. Box 1171 Blindern, 0318, Oslo, Norway; The Circulation Laboratory, Department of Cardiothoracic Surgery, Oslo University Hospital HF, Postboks 4950 Nydalen, 0424, Oslo, Norway. Electronic address: b24427@ous-hf.no.
Takuma MiyamotoLerner Research Institute, Department of Biomedical Engineering, 9500 Euclid Ave, ND20, Cleveland, OH, 44195, USA. Electronic address: miyamot@ccf.org.
Ane Hasle SporastøylThe Circulation Laboratory, Department of Cardiothoracic Surgery, Oslo University Hospital HF, Postboks 4950 Nydalen, 0424, Oslo, Norway; The Medical Student Research Program, Faculty of Medicine, University of Oslo, P.O. Box 1078 Blindern, 0318, Oslo, Norway. Electronic address: ane_hsp@hotmail.com.
Liv Kristin WikslundThe Circulation Laboratory, Department of Cardiothoracic Surgery, Oslo University Hospital HF, Postboks 4950 Nydalen, 0424, Oslo, Norway; The Medical Student Research Program, Faculty of Medicine, University of Oslo, P.O. Box 1078 Blindern, 0318, Oslo, Norway. Electronic address: livsundheim@gmail.com.
Svein-Erik MåsøyODI Medical AS, Gaustadalléen 21, 0349, Oslo, Norway. Electronic address: svein-erik.masoy@odimedical.com.
Liv DrolsumDepartment of Ophthalmology, Oslo University Hospital HF, Postboks 4950 Nydalen, 0424, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, P.O. Box 1171 Blindern, 0318, Oslo, Norway. Electronic address: liv.drolsum@medisin.uio.no.
Morten Carstens MoeDepartment of Ophthalmology, Oslo University Hospital HF, Postboks 4950 Nydalen, 0424, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, P.O. Box 1171 Blindern, 0318, Oslo, Norway. Electronic address: m.c.moe@medisin.uio.no.
Goran SalerudDepartment of Biomedical Engineering, Linkoping University, Campus US, SE-581 83, Linkoping, Sweden. Electronic address: goran.salerud@liu.se.
Kiyotaka FukamachiLerner Research Institute, Department of Biomedical Engineering, 9500 Euclid Ave, ND20, Cleveland, OH, 44195, USA. Electronic address: FUKAMAK@ccf.org.
Knut KverneboInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, P.O. Box 1171 Blindern, 0318, Oslo, Norway; The Circulation Laboratory, Department of Cardiothoracic Surgery, Oslo University Hospital HF, Postboks 4950 Nydalen, 0424, Oslo, Norway. Electronic address: knut.kvernebo@odimedical.com.
Oslo University Hospital · NOCleveland Clinic Lerner College of Medicine · USLinköping University · SENorwegian Computing Center · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In piglets we tested the applicability of digital video microscopy and diffuse reflectance spectroscopy for non-invasive assessments of limbal and bulbar conjunctival microcirculation. A priori we postulated that the metabolic rate is higher in limbal as compared to bulbar conjunctiva, and that this difference is reflected in microvascular structure or function between the two locations. Two study sites, Oslo University Hospital (OUH), Norway and Cleveland Clinic (CC), USA, used the same video microscopy and spectroscopy techniques to record limbal and bulbar microcirculation in sleeping piglets. Recordings were analyzed with custom-made software to quantify functional capillary density, capillary flow velocity and microvascular oxygen saturation in measuring volumes of approximately 0.1 mm

Indexed as

AnimalsBlood Flow VelocityConjunctivaFemaleImage Processing, Computer-AssistedMaleMicrocirculationMicroscopy, VideoMicrovesselsModels, AnatomicModels, AnimalSpectrum AnalysisSwineAugust kroghCapillary flow velocityConjunctival microcirculationFunctional capillary densityLimbal microcirculationMicrovascular oxygen saturationODIN concept

Identifiers

PMID33157128
PMCPMC7581323
OpenAlexW3093502204

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.