Evidence map›Paper›PMID 33157375›Full record

ReviewEnvironment international2021

Ionizing radiation-induced circulatory and metabolic diseases.

Soile Tapio, Mark P Little, Jan Christian Kaiser, Nathalie Impens, Nobuyuki Hamada, Alexandros G Georgakilas, David Simar, Sisko Salomaa

Open access · goldAbstract readReview
In one paragraph

Review in Environment international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 3 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 3 syntheses or guidelines pooled it, 139 citations in OpenAlex.

  1. Biological effects of high-LET irradiation on the circulatory system.International journal of radiation biology · 2025
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Transient bradycardia duringAnnals of nuclear medicine · 2026
    Article
  7. Article
  8. Article
  9. Radiomitigators: Breakthroughs in Post-Radiation Recovery.Antioxidants (Basel, Switzerland) · 2026
    Review
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  11. Article
  12. Article
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  15. Article
  16. Article
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  18. Review
  19. Review
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 6 countries.

Soile TapioInstitute of Radiation Biology, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health GmbH, Neuherberg, Germany. Electronic address: soile.tapio@helmholtz-muenchen.de.
Mark P LittleRadiation Epidemiology Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), MD, USA.
Jan Christian KaiserInstitute of Radiation Medicine, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health GmbH, Neuherberg, Germany.
Nathalie ImpensInstitute of Environment, Health and Safety, Biosphere Impact Studies, SCK•CEN, Mol, Belgium.
Nobuyuki HamadaRadiation Safety Research Center, Nuclear Technology Research Laboratory, Central Research Institute of Electric Power Industry (CRIEPI), Tokyo, Japan.
Alexandros G GeorgakilasDNA Damage Laboratory, Department of Physics, School of Applied Mathematical and Physical Sciences, National Technical University of Athens (NTUA), Athens, Greece.
David SimarMechanisms of Disease and Translational Research, School of Medical Sciences, UNSW Sydney, Sydney, Australia.
Sisko SalomaaDepartment of Environmental and Biological Sciences, University of Eastern Finland, Kuopio, Finland.
Helmholtz Zentrum München · DECentral Research Institute of Electric Power Industry · JPNational Cancer Institute · USNational Technical University of Athens · GRUniversity of Eastern Finland · FIUNSW Sydney · AU

Funding

Studies of Populations Exposed to Environmental Sources of RadiationZIACP010132 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI CAHOON, ELIZABETH · 2009 to 2025
$35.2M
Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

Risks to health are the prime consideration in all human situations of ionizing radiation exposure and therefore of relevance to radiation protection in all occupational, medical, and public exposure situations. Over the past few decades, advances in therapeutic strategies have led to significant improvements in cancer survival rates. However, a wide range of long-term complications have been reported in cancer survivors, in particular circulatory diseases and their major risk factors, metabolic diseases. However, at lower levels of exposure, the evidence is less clear. Under real-life exposure scenarios, including radiotherapy, radiation effects in the whole organism will be determined mainly by the response of normal tissues receiving relatively low doses, and will be mediated and moderated by systemic effects. Therefore, there is an urgent need for further research on the impact of low-dose radiation. In this article, we review radiation-associated risks of circulatory and metabolic diseases in clinical, occupational or environmental exposure situations, addressing epidemiological, biological, risk modelling, and systems biology aspects, highlight the gaps in knowledge and discuss future directions to address these gaps.

Indexed as

Cardiovascular DiseasesMetabolic DiseasesOccupational ExposureRadiation InjuriesEnvironmental ExposureHumansRadiation, IonizingCirculatory diseaseEndothelialHeartIonizing radiationMetabolic syndromeRadiotherapySystems biology

Identifiers

PMID33157375
PMCPMC10686049
OpenAlexW3094683316

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.