Evidence map›Paper›PMID 33158965›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

ERα Signaling in GHRH/Kiss1 Dual-Phenotype Neurons Plays Sex-Specific Roles in Growth and Puberty.

David Garcia-Galiano, Alexandra L Cara, Zachary Tata, Susan J Allen, Martin G Myers, Ernestina Schipani, Carol F Elias

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Liver-specific actions of GH and IGF1 that protect against MASLD.Nature reviews. Endocrinology · 2025 · on this map
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Chemical Composition and Biological Properties of TwoAntioxidants (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 5 countries.

David Garcia-GalianoDepartment of Molecular and Integrative Physiology bc2gagad@uco.es.ORCID 0000-0001-9506-8785
Alexandra L CaraDepartment of Molecular and Integrative Physiology.
Zachary TataDepartment of Orthopedic Surgery, Medicine, and Cell and Developmental Biology.
Susan J AllenDepartment of Molecular and Integrative Physiology.
Martin G MyersDepartment of Molecular and Integrative Physiology.
Ernestina SchipaniDepartment of Orthopedic Surgery, Medicine, and Cell and Developmental Biology.
Carol F EliasDepartment of Molecular and Integrative Physiology.ORCID 0000-0001-9878-9203
Laboratoire d’immunologie intégrative du cancer · FRShanghai Cell Therapy Research Institute · CNDiabetes Australia · AUShiga University · JPUniversity of Michigan · US

Funding

PUBLIC HEALTH DEMONSTRATIONP60DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MYERS, MARTIN G · 1985 to 2012
$26.5M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Karen Eileen Peterson · 2010 to 2026
$20.3M
Michigan Mouse Metabolic Phenotyping CenterU2CDK110768 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELIAS, CAROL FUZETI · 2016 to 2021
$6.2M
MOLECULAR DETERMINANTS OF LEPTIN RECEPTOR/JAK2 SIGNALINGR01DK056731 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MYERS, MARTIN G · 1999 to 2025
$6.0M
Molecular Mechanisms of Leptin Receptor/Jak2 ActionR37DK056731 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MYERS, MARTIN G · 2008 to 2017
$3.5M
Neural basis of leptin action on reproductionR01HD069702 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI ELIAS, CAROL FUZETI · 2012 to 2021
$3.4M
Career Training in Reproductive BiologyT32HD079342 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Suzanne M MOENTER · 2014 to 2026
$2.3M
CRR LIGAND ASSAY AND ANALYSIS CORER24HD102061 · NICHD · UNIVERSITY OF VIRGINIA · PI HAISENLEDER, DANIEL J. · 2019 to 2023
$2.2M
Mitochondria and TFAM in Osteoblast BiologyR01AR074079 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI SCHIPANI, ERNESTINA · 2019 to 2024
$2.0M
Integrative Approaches to Decipher Genetic Determinants of Disease Penetrance in Prokineticin 2 Pathway Related Human Reproductive DisordersR01HD096324 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI BALASUBRAMANIAN, RAVIKUMAR · 2018 to 2022
$1.7M
NIAMS NIH HHS R01 AR074079NICHD NIH HHS R01 HD069702NICHD NIH HHS R01 HD096324NICHD NIH HHS R24 HD102061NICHD NIH HHS T32 HD079342NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK089503NIDDK NIH HHS P60 DK020572NIDDK NIH HHS R01 DK056731NIDDK NIH HHS R37 DK056731NIDDK NIH HHS U2C DK110768
6 · The paper itself

Abstract

Gonadal steroids modulate growth hormone (GH) secretion and the pubertal growth spurt via undefined central pathways. GH-releasing hormone (GHRH) neurons express estrogen receptor α (ERα) and androgen receptor (AR), suggesting changing levels of gonadal steroids during puberty directly modulate the somatotropic axis. We generated mice with deletion of ERα in GHRH cells (GHRH

Indexed as

AnimalsEstrogen Receptor alphaFemaleGonadal Steroid HormonesGrowthGrowth Hormone-Releasing HormoneHypothalamusKisspeptinsMaleMiceMice, KnockoutReceptors, AndrogenSex CharacteristicsSexual MaturationSignal TransductionEsr1 protein, mouseEstrogen Receptor alphaGonadal Steroid HormonesGrowth Hormone-Releasing HormoneKiss1 protein, mouseKisspeptinsReceptors, Androgenandrogen receptorboneestrogen receptor αKiss1reproduction

Identifiers

PMID33158965
PMCPMC7724138
OpenAlexW3096368840

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.