Evidence map›Paper›PMID 33163675›Full record

ArticleHeliyon2020

The impact of curcumin-graphene based nanoformulation on cellular interaction and redox-activated apoptosis: An

Lina A Al-Ani, Farkaad A Kadir, Najihah M Hashim, Nurhidayatullaili M Julkapli, Ali Seyfoddin, Jun Lu, Mohammed A AlSaadi, Wageeh A Yehye

Open access · goldAbstract read
In one paragraph

Article in Heliyon, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Lina A Al-AniInstitute of Advanced Studies, Nanotechnology & Catalysis Research Centre (NANOCAT), University of Malaya, Kuala Lumpur, Malaysia.
Farkaad A KadirDepartment of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Najihah M HashimDepartment of Pharmaceutical Chemicals, Faculty of Pharmacy, University of Malaya, Kuala Lumpur, Malaysia.
Nurhidayatullaili M JulkapliInstitute of Advanced Studies, Nanotechnology & Catalysis Research Centre (NANOCAT), University of Malaya, Kuala Lumpur, Malaysia.
Ali SeyfoddinDrug Delivery Research Group, Auckland University of Technology, School of Science, Auckland, New Zealand.
Jun LuSchool of Science, Faculty of Health & Environmental Sciences, Auckland University of Technology. Auckland, New Zealand.
Mohammed A AlSaadiInstitute of Advanced Studies, Nanotechnology & Catalysis Research Centre (NANOCAT), University of Malaya, Kuala Lumpur, Malaysia.
Wageeh A YehyeInstitute of Advanced Studies, Nanotechnology & Catalysis Research Centre (NANOCAT), University of Malaya, Kuala Lumpur, Malaysia.
University of Malaya · MYAuckland University of Technology · NZUniversity of Auckland · NZUniversity of Nizwa · OM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural plants derivatives have gained enormous merits in cancer therapy applications upon formulation with nanomaterials. Curcumin, as a popular research focus has acquired such improvements surpassing its disadvantageous low bioavailability. To this point, the available research data had confirmed the importance of nanomaterial type in orienting cellular response and provoking different toxicological and death mechanisms that may range from physical membrane damage to intracellular changes. This in turn underlines the poorly studied field of nanoformulation interaction with cells as the key determinant in toxicology outcomes. In this work, curcumin-AuNPs-reduced graphene oxide nanocomposite (CAG) was implemented as a model, to study the impact on cellular membrane integrity and the possible redox changes using colon cancer

Indexed as

AnticancerApoptosisCancer researchCell biologyCell membraneNanotechnologyNatural productsOxidative stress

Identifiers

PMID33163675
PMCPMC7609448
OpenAlexW3095005736

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.