Evidence map›Paper›PMID 33169670›Full record

ArticleeLife2020

Innovation of heterochromatin functions drives rapid evolution of essential ZAD-ZNF genes in

Bhavatharini Kasinathan, Serafin U Colmenares, Hannah McConnell, Janet M Young, Gary H Karpen, Harmit S Malik

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 50 citations in OpenAlex.

  1. Cross-species incompatibilities offer new insights into the functional consequences of satellite DNA evolution.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026
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  5. Sex-biased duplicates are rapidly generated duringbioRxiv : the preprint server for biology · 2025
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  11. Escalation of genome defense capacity enables control of an expanding meiotic driver.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Orphan genes are not a distinct biological entity.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Bhavatharini KasinathanMedical Scientist Training Program, University of Washington School of Medicine, Seattle, United States.ORCID 0000-0001-7053-5826
Serafin U ColmenaresBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, United States.ORCID 0000-0002-4094-4220
Hannah McConnellDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States.
Janet M YoungDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States.ORCID 0000-0001-8220-8427
Gary H KarpenBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, United States.ORCID 0000-0003-1534-0385
Harmit S MalikDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States.ORCID 0000-0001-6005-0016
Fred Hutch Cancer Center · USLawrence Berkeley National Laboratory · USHoward Hughes Medical Institute · USUniversity of Washington · US

Funding

Chromosome Metabolism and Cancer Training GrantT32CA009657 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI EISENMAN, ROBERT NEIL · 1991 to 2020
$7.6M
Genetic Conflict Shapes Centromeres and HeterochromatinR01GM074108 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MALIK, HARMIT S. · 2005 to 2022
$6.1M
Organization and Function of the Heterochromatin Holodomain and SubdomainsR01GM117420 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KARPEN, GARY H · 2016 to 2019
$2.5M
Functional consequences of increased centromere size in mitosis and meiosisF30CA225077 · NCI · UNIVERSITY OF WASHINGTON · PI KASINATHAN, BHAVATHARINI · 2018 to 2020
$132k
Howard Hughes Medical InstituteNCI NIH HHS F30 CA225077NCI NIH HHS T32 CA009657NIGMS NIH HHS R01 GM074108NIGMS NIH HHS R01 GM117420
6 · The paper itself

Abstract

Contrary to dogma, evolutionarily young and dynamic genes can encode essential functions. We find that evolutionarily dynamic

Indexed as

AnimalsDrosophila melanogasterDrosophila ProteinsEvolution, MolecularFemaleGenes, InsectHeterochromatinMalePhylogenyTranscription FactorsDrosophila ProteinsHeterochromatinNnk protein, DrosophilaTranscription FactorschromatinD. melanogasterevolutionary biologygene essentialitygeneticsgene turnovergenomicsheterochromatinkrab-zinc fingerpositive selection

Identifiers

PMID33169670
PMCPMC7655104
OpenAlexW3099998011

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.