ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2020
Multiscale Characterization of Embryonic Long Bone Mineralization in Mice.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
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- Multimodal Characterization of Rodent Dental Development.ACS applied materials & interfaces · 2025Article
- Multi-modal characterization of rodent tooth development.bioRxiv : the preprint server for biology · 2024Article
- Crossing length scales: X-ray approaches to studying the structure of biological materials.IUCrJ · 2024Review
- Elemental and Structural Characterization of Heterotopic Ossification during Achilles Tendon Healing Provides New Insights on the Formation Process.ACS biomaterials science & engineering · 2024Article
- Zinc-alkaline phosphatase at sites of aortic calcification.Journal of molecular histology · 2024Article
- In Situ Loading and Time-Resolved Synchrotron-Based Phase Contrast Tomography for the Mechanical Investigation of Connective Knee Tissues: A Proof-of-Concept Study.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Design and performance of a dedicated coherent X-ray scanning diffraction instrument at beamline NanoMAX of MAX IV.Journal of synchrotron radiation · 2022Article
- Dose-efficient multimodal microscopy of human tissue at a hard X-ray nanoprobe beamline.Journal of synchrotron radiation · 2022Article
- X-ray in-line holography and holotomography at the NanoMAX beamline.Journal of synchrotron radiation · 2022Article
- NanoMAX: the hard X-ray nanoprobe beamline at the MAX IV Laboratory.Journal of synchrotron radiation · 2021Article
- Multiscale Characterization of Embryonic Long Bone Mineralization in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long bone mineralization occurs through endochondral ossification, where a cartilage template mineralizes into bone-like tissue with a hierarchical organization from the whole bone-scale down to sub-nano scale. Whereas this process has been extensively studied at the larger length scales, it remains unexplored at some of the smaller length scales. In this study, the changes in morphology, composition, and structure during embryonic mineralization of murine humeri are investigated using a range of high-resolution synchrotron-based imaging techniques at several length scales. With micro- and nanometer spatial resolution, the deposition of elements and the shaping of mineral platelets are followed. Rapid mineralization of the humeri occurs over approximately four days, where mineral to matrix ratio and calcium content in the most mineralized zone reach adult values shortly before birth. Interestingly, zinc is consistently found to be localized at the sites of ongoing new mineralization. The mineral platelets in the most recently mineralized regions are thicker, longer, narrower, and less aligned compared to those further into the mineralized region. In summary, this study demonstrates a specific spatial distribution of zinc, with highest concentration where new mineral is being deposited and that the newly formed mineral platelets undergo slight reshaping and reorganization during embryonic development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.