Evidence map›Paper›PMID 33177203›Full record

ArticleJournal of virology2021

Human Cytomegalovirus Interactions with the Basement Membrane Protein Nidogen 1.

Man I Kuan, Hannah K Jaeger, Onesmo B Balemba, John M O'Dowd, Deborah Duricka, Holger Hannemann, Emmerentia Marx, Natacha Teissier, Liliana Gabrielli, Maria Paola Bonasoni and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Man I KuanDepartment of Biological Sciences and Center for Reproductive Biology, University of Idaho, Moscow, Idaho, USA.
Hannah K JaegerDepartment of Biological Sciences and Center for Reproductive Biology, University of Idaho, Moscow, Idaho, USA.
Onesmo B BalembaDepartment of Biological Sciences and Center for Reproductive Biology, University of Idaho, Moscow, Idaho, USA.
John M O'DowdDepartment of Biological Sciences and Center for Reproductive Biology, University of Idaho, Moscow, Idaho, USA.
Deborah DurickaDepartment of Biological Sciences and Center for Reproductive Biology, University of Idaho, Moscow, Idaho, USA.
Holger HannemannThe Native Antigen Co., Langford Locks, Kidlington, Oxfordshire, United Kingdom.
Emmerentia MarxDepartment of Biological Sciences and Center for Reproductive Biology, University of Idaho, Moscow, Idaho, USA.
Natacha TeissierPediatric ENT Department, Robert Debré Hospital, NeuroDiderot, Université de Paris, Paris, France.
Liliana GabrielliOperative Unit of Clinical Microbiology, St. Orsola Polyclinic, University of Bologna, Bologna, Italy.
Maria Paola BonasoniPathology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS, Reggio Emilia, Italy.
Elizabeth M KeithleyDivision of Otolaryngology/Head and Neck Surgery, UC San Diego, La Jolla, California, USA.
Elizabeth A FortunatoDepartment of Biological Sciences and Center for Reproductive Biology, University of Idaho, Moscow, Idaho, USA lfort@uidaho.edu.ORCID 0000-0003-2212-3645
University of Idaho · USOspedale Santa Maria · ITUniversité Paris Cité · FRUniversity of Bologna · ITUniversity of California San Diego · US

Funding

UNDERGRADUATE COLLEGE OUTREACH PROGRAMP20RR016454 · NCRR · UNIVERSITY OF IDAHO · PI HOVDE, CAROLYN J · 2001 to 2011
$35.3M
Sequence-structure-function relationships in human visual photopigmentsP20GM104420 · NIGMS · UNIVERSITY OF IDAHO · PI VAN LEUVEN, JAMES · 2015 to 2024
$22.9M
HCMV infection downregulates nidogen 1 and myelin protein zeroR01AI139503 · NIAID · UNIVERSITY OF IDAHO · PI ELIZABETH A FORTUNATO · 2018 to 2026
$2.9M
Repair of HCMV-Induced DNA Damage in Infected CellsR01AI051463 · NIAID · UNIVERSITY OF IDAHO · PI FORTUNATO, ELIZABETH A · 2003 to 2014
$2.7M
Chromosome 1 Damage in HCMV Infected CellsR21AI051463 · NIAID · UNIVERSITY OF IDAHO · PI FORTUNATO, ELIZABETH A · 2002 to 2002
$286k
NCRR NIH HHS P20 RR016454NIAID NIH HHS R01 AI051463NIAID NIH HHS R01 AI139503NIAID NIH HHS R21 AI051463NIGMS NIH HHS P20 GM104420
6 · The paper itself

Abstract

In 2000, we reported that human cytomegalovirus (HCMV) induced specific damage on chromosome 1. The capacity of the virus to induce DNA breaks indicated potent interaction between viral proteins and these loci. We have fine mapped the 1q42 breaksite. Transcriptional analysis of genes encoded in close proximity revealed virus-induced downregulation of a single gene,

Indexed as

Basement MembraneCell MovementCytomegalovirusCytomegalovirus InfectionsEndothelium, VascularFibroblastsHumansMembrane GlycoproteinsSignal TransductionVirus InternalizationMembrane Glycoproteinsnidogenbasement membranechromosome mappingcongenital infectionshuman cytomegalovirusnidogen 1transmigrationvirus/host interaction

Identifiers

PMID33177203
PMCPMC7925088
OpenAlexW3100117439

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.