ArticleScientific reports2020
UPLC/MS-based untargeted metabolomics reveals the changes of metabolites profile of Salvia miltiorrhiza bunge during Sweating processing.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Enhanced Biocontrol of Root-Knot Nematodes Through Co-Cultivation ofJournal of fungi (Basel, Switzerland) · 2026Article
- Microbial community variation enhances active compound composition in Salvia miltiorrhiza.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- The effect of high-fat diet on serum metabolites in rats with heart failure: a non-targeted metabolomics approach.BMC cardiovascular disorders · 2025Article
- Effects of post-harvest ' rubbing-sweating ' drying treatment on the accumulation of bioactive compounds inFrontiers in plant science · 2025Article
- Landscapes of the main components, metabolic and microbial signatures, and their correlations during stack "sweating" ofFrontiers in microbiology · 2025Article
- Comparative Analysis of the Chemical Constituents ofMetabolites · 2024Article
- Simulated LC-MS Data Set for Assessing the Metabolomics Data Processing Pipeline Implemented into MVAPACK.Analytical chemistry · 2024Article
- Comparative efficacy of sweated and non-sweatedHeliyon · 2024Article
- The sweating process promotes toxigenic fungi expansion and increases the risk of combined contamination of mycotoxins inFrontiers in microbiology · 2024Article
- The foundation of the rhubarb industry economy: investigating metabolites disparities of rhubarb between varieties and growing environments on the Tibetan plate.Frontiers in pharmacology · 2024Article
- Codonopsis radix: a review of resource utilisation, postharvest processing, quality assessment, and its polysaccharide composition.Frontiers in pharmacology · 2024Review
- Regulation of the Gene for Alanine Racemase Modulates Amino Acid Metabolism with Consequent Alterations in Cell Wall Properties and Adhesive Capability inInternational journal of molecular sciences · 2023Article
- Network pharmacology and molecular docking of endogenous active metabolites in diabetic kidney disease.Renal failure · 2023Article
- A physiological and metabolomic analysis reveals the effect of shading intensity on blueberry fruit quality.Food chemistry: X · 2022Article
- Metabolite Profiling and Classification of Highbush Blueberry Leaves under Different Shade Treatments.Metabolites · 2022Article
- ICP-MS based metallomics and GC-MS based metabolomics reveals the physiological and metabolic responses ofFrontiers in nutrition · 2022Article
- Rapid quantification of bioactive compounds inFrontiers in chemistry · 2022Article
- Serum Metabolomics Benefits Discrimination Kidney Disease Development in Type 2 Diabetes Patients.Frontiers in medicine · 2022Article
- Vacuum pressure combined with osmosonication as an innovative pre-drying technique for Ghanaian ginger: Evidence from the metabolome and quality characteristics of the dried product.Ultrasonics sonochemistry · 2021Article
- Metabolite Profiling and Transcriptome Analysis Provide Insight into Seed Coat Color inInternational journal of molecular sciences · 2021Article
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8 authors.
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Abstract
Salvia miltiorrhiza has numerous compounds with extensive clinical application. "Sweating", a processing method of Traditional Chinese Medicine (TCM), results in great changes in pharmacology and pharmacodynamics. Previously, chromatogram of 10 characteristic metabolites in S. miltiorrhiza showed a significant difference after "Sweating". Due to the complexity of TCM, changes in metabolites should be investigated metabolome-wide after "Sweating". An untargeted UPLC/MS-based metabolomics was performed to discover metabolites profile variation of S. miltiorrhiza after "Sweating". Multivariate analysis was conducted to screen differential metabolites. Analysis indicated distinct differences between sweated and non-sweated samples. 10,108 substance peaks had been detected altogether, and 4759 metabolites had been identified from negative and positive ion model. 287 differential metabolites were screened including 112 up-regulated and 175 down-regulated and they belong to lipids and lipid-like molecules, and phenylpropanoid and polyketides. KEGG analysis showed the pathway of linoleic acid metabolism, and glyoxylate and dicarboxylate metabolism were mainly enriched. 31 and 49 identified metabolites were exclusively detected in SSM and NSSM, respectively, which mainly belong to carboxylic acids and derivatives, polyketides and fatty acyls. By mapping tanshinones and salvianolic acids to 4759 identified metabolites library, 23 characteristic metabolites had been identified, among which 11 metabolites changed most. We conclude that "Sweating'' has significant effect on metabolites content and composition of S. miltiorrhiza.
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