Evidence map›Paper›PMID 33178681›Full record

ArticleFrontiers in cell and developmental biology2020

DNA Methylation Associated With Diabetic Kidney Disease in Blood-Derived DNA.

Laura J Smyth, Christopher C Patterson, Elizabeth J Swan, Alexander P Maxwell, Amy Jayne McKnight

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
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  7. Integrated multiomic analyses: An approach to improve understanding of diabetic kidney disease.Diabetic medicine : a journal of the British Diabetic Association · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Laura J SmythCentre for Public Health, Queen's University Belfast, Belfast, United Kingdom.
Christopher C PattersonCentre for Public Health, Queen's University Belfast, Belfast, United Kingdom.
Elizabeth J SwanCentre for Public Health, Queen's University Belfast, Belfast, United Kingdom.
Alexander P MaxwellCentre for Public Health, Queen's University Belfast, Belfast, United Kingdom.
Amy Jayne McKnightCentre for Public Health, Queen's University Belfast, Belfast, United Kingdom.
Queen's University Belfast · GB

Funding

Integrative genomic, epigenetic and functional studies in diabetic kidney diseaseR01DK105154 · NIDDK · BROAD INSTITUTE, INC. · PI FLOREZ, JOSE CARLOS, HIRSCHHORN, JOEL N · 2016 to 2019
$3.0M
Medical Research Council MC_PC_15025NIDDK NIH HHS R01 DK105154
6 · The paper itself

Abstract

A subset of individuals with type 1 diabetes will develop diabetic kidney disease (DKD). DKD is heritable and large-scale genome-wide association studies have begun to identify genetic factors that influence DKD. Complementary to genetic factors, we know that a person's epigenetic profile is also altered with DKD. This study reports analysis of DNA methylation, a major epigenetic feature, evaluating methylome-wide loci for association with DKD. Unique features (

Indexed as

associationdiabetesepigenetickidneymethylationrenal

Identifiers

PMID33178681
PMCPMC7593403
OpenAlexW3092681982

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.