Evidence map›Paper›PMID 33182772›Full record

ReviewCells2020

Scavenger Receptors as Biomarkers and Therapeutic Targets in Cardiovascular Disease.

Gary A Cuthbert, Faheem Shaik, Michael A Harrison, Sreenivasan Ponnambalam, Shervanthi Homer-Vanniasinkam

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Gary A CuthbertFaculty of Medicine and Health, University of Leeds, Leeds LS2 9JT, UK.
Faheem ShaikSchool of Molecular & Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.
Michael A HarrisonSchool of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK.
Sreenivasan PonnambalamSchool of Molecular & Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.ORCID 0000-0002-4452-7619
Shervanthi Homer-VanniasinkamFaculty of Medicine and Health, University of Leeds, Leeds LS2 9JT, UK.
University of Leeds · GB

Funding

British Heart Foundation FS/17/30/32832
6 · The paper itself

Abstract

The process of atherosclerosis leads to the formation of plaques in the arterial wall, resulting in a decreased blood supply to tissues and organs and its sequelae: morbidity and mortality. A class of membrane-bound proteins termed scavenger receptors (SRs) are closely linked to the initiation and progression of atherosclerosis. Increasing interest in understanding SR structure and function has led to the idea that these proteins could provide new routes for cardiovascular disease diagnosis, management, and treatment. In this review, we consider the main classes of SRs that are implicated in arterial disease. We consider how our understanding of SR-mediated recognition of diverse ligands, including modified lipid particles, lipids, and carbohydrates, has enabled us to better target SR-linked functionality in disease. We also link clinical studies on vascular disease to our current understanding of SR biology and highlight potential areas that are relevant to cardiovascular disease management and therapy.

Indexed as

AtherosclerosisBiomarkersCardiovascular DiseasesHumansReceptors, ScavengerBiomarkersReceptors, Scavengeratherosclerosiscardiovascular diseaselipidsscavenger receptors

Identifiers

PMID33182772
PMCPMC7696859
OpenAlexW3102273604

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.