ArticleCirculation research2021
Intracellular β
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Article in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
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Who cites it
44 citing papers in PubMed, 76 citations in OpenAlex.
- Inhibitory probes for spatiotemporal analysis of GαNature chemical biology · 2026Article
- AKAP6β-a conductor in the orchestra of pathological cardiomyocyte gene transcription.Molecular pharmacology · 2026Review
- Decoding the shared genetic architecture of atherosclerotic cardiovascular disease: a genomic structural equation modeling analysis.BMC cardiovascular disorders · 2026Article
- β-Adrenergic Receptors: Not Always Outside-In.Physiology (Bethesda, Md.) · 2026Review
- Intracrine FFA4 signaling controls lipolysis at lipid droplets.Nature chemical biology · 2026Article
- The beta1-adrenergic receptor in the heart.Cell death discovery · 2025Review
- Autonomic imbalance in cardiovascular disease: molecular mechanisms and emerging therapeutics.American journal of physiology. Cell physiology · 2025Review
- Exercise-induced dysregulation of the adrenergic response in a mouse model of PKP2-arrhythmogenic cardiomyopathy.Heart rhythm · 2025Article
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- Unique Role of Intracellular Perinuclear βCirculation · 2025Article
- Inhibition of the upregulated phosphodiesterase 4D isoforms improves SERCA2a function in diabetic cardiomyopathy.British journal of pharmacology · 2025Article
- Nanodomain cAMP signaling in cardiac pathophysiology: potential for developing targeted therapeutic interventions.Physiological reviews · 2025Review
- Purinergic Receptor P2Y1 Modulates Catecholamine Signaling in Murine Mesenteric Lymph Nodes.ACS chemical neuroscience · 2025Article
- Phosphodiesterases: Evolving Concepts and Implications for Human Therapeutics.Annual review of pharmacology and toxicology · 2025Review
- Subcellular activation of β-adrenergic receptors using a spatially restricted antagonist.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Activation of IPAmerican journal of physiology. Heart and circulatory physiology · 2024Article
- Carvedilol Activates a Myofilament Signaling Circuitry to Restore Cardiac Contractility in Heart Failure.JACC. Basic to translational science · 2024Article
- Unheralded Adrenergic Receptor Signaling in Cellular Oxidative Stress and Death.Current opinion in physiology · 2024Article
- Internalized β2-Adrenergic Receptors Oppose PLC-Dependent Hypertrophic Signaling.Circulation research · 2024Article
- Differential Downregulation of βJournal of the American Heart Association · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 7 institutions in 3 countries.
Ying WangDepartment of Pharmacology, University of California at Davis (Y.W., Q.S., M.L., M.Z., R.R.G., J.-P.T., B.X., C.Z., K.E.I., S.S., J.B., J.W.H., D.M.B., Y.K.X.).
Qian ShiDepartment of Pharmacology, University of California at Davis (Y.W., Q.S., M.L., M.Z., R.R.G., J.-P.T., B.X., C.Z., K.E.I., S.S., J.B., J.W.H., D.M.B., Y.K.X.).
Minghui LiDepartment of Pharmacology, University of California at Davis (Y.W., Q.S., M.L., M.Z., R.R.G., J.-P.T., B.X., C.Z., K.E.I., S.S., J.B., J.W.H., D.M.B., Y.K.X.).
Meimi ZhaoDepartment of Pharmacology, University of California at Davis (Y.W., Q.S., M.L., M.Z., R.R.G., J.-P.T., B.X., C.Z., K.E.I., S.S., J.B., J.W.H., D.M.B., Y.K.X.).
Raghavender Reddy GopireddyDepartment of Pharmacology, University of California at Davis (Y.W., Q.S., M.L., M.Z., R.R.G., J.-P.T., B.X., C.Z., K.E.I., S.S., J.B., J.W.H., D.M.B., Y.K.X.).
Jian-Peng TeohDepartment of Pharmacology, University of California at Davis (Y.W., Q.S., M.L., M.Z., R.R.G., J.-P.T., B.X., C.Z., K.E.I., S.S., J.B., J.W.H., D.M.B., Y.K.X.).
Bing XuDepartment of Pharmacology, University of California at Davis (Y.W., Q.S., M.L., M.Z., R.R.G., J.-P.T., B.X., C.Z., K.E.I., S.S., J.B., J.W.H., D.M.B., Y.K.X.).
Chaoqun ZhuDepartment of Pharmacology, University of California at Davis (Y.W., Q.S., M.L., M.Z., R.R.G., J.-P.T., B.X., C.Z., K.E.I., S.S., J.B., J.W.H., D.M.B., Y.K.X.).
Kyle E IretonDepartment of Pharmacology, University of California at Davis (Y.W., Q.S., M.L., M.Z., R.R.G., J.-P.T., B.X., C.Z., K.E.I., S.S., J.B., J.W.H., D.M.B., Y.K.X.).
Sanghavi SrinivasanDepartment of Pharmacology, University of California at Davis (Y.W., Q.S., M.L., M.Z., R.R.G., J.-P.T., B.X., C.Z., K.E.I., S.S., J.B., J.W.H., D.M.B., Y.K.X.).
Shaoliang ChenNanjing First Hospital, Nanjing Medical University, China (M.L., S.C.).
Paul J GasserDepartment of Biomedical Sciences, Marquette University, Milwaukee, WI (P.J.G.).
Julie BossuytDepartment of Pharmacology, University of California at Davis (Y.W., Q.S., M.L., M.Z., R.R.G., J.-P.T., B.X., C.Z., K.E.I., S.S., J.B., J.W.H., D.M.B., Y.K.X.).
Johannes W HellDepartment of Pharmacology, University of California at Davis (Y.W., Q.S., M.L., M.Z., R.R.G., J.-P.T., B.X., C.Z., K.E.I., S.S., J.B., J.W.H., D.M.B., Y.K.X.).
Donald M BersDepartment of Pharmacology, University of California at Davis (Y.W., Q.S., M.L., M.Z., R.R.G., J.-P.T., B.X., C.Z., K.E.I., S.S., J.B., J.W.H., D.M.B., Y.K.X.).
Yang K XiangDepartment of Pharmacology, University of California at Davis (Y.W., Q.S., M.L., M.Z., R.R.G., J.-P.T., B.X., C.Z., K.E.I., S.S., J.B., J.W.H., D.M.B., Y.K.X.).
Maine Farmland Trust · USWorld Wide Web Consortium · USDr. Reddy's Laboratories (United States) · USMarquette University · USNanjing Medical University · CNOregon Health & Science University · USZunyi Medical University · CN
Funding
Project 3 (Mercola)P01HL141084 · NHLBI · STANFORD UNIVERSITY · PI MARK MERCOLA · 2019 to 2026
$21.1MRole of a-actinin in Cav1.2 FunctionR01AG055357 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JOHANNES W HELL · 2016 to 2026
$4.0MMolecular Mechanisms of Postsynaptic AMPA Receptor LocalizationR01MH097887 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2014 to 2018
$2.5MInsulin Inhibition of beta-AR Signaling in the MyocardiumR01HL127764 · NHLBI · UNIVERSITY OF IOWA · PI ABEL, E DALE, XIANG, YANG K · 2015 to 2018
$2.4MLearning, Memory, and Plasticity (LaMP) Training ProgramT32MH112507 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Karen Zito · 2017 to 2026
$2.4MSignaling by cAMP within postsynaptic nano domains R01NS078792R01NS078792 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2016
$2.0MAKAP-dependent regulation of Cardiac SR Ca handlingR01HL133832 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M · 2017 to 2020
$2.0MMolecular Regulation of cardiac adrenergic signalingR01HL147263 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI XIANG, YANG K · 2019 to 2022
$1.7MNovel mechanism on subpopulation-dependent biased GPCR signaling in neuronsR01GM129376 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI XIANG, YANG K · 2018 to 2021
$1.6MMolecular mechanisms of Insulin resistance under chronic stressI01BX002900 · VA · VA NORTHERN CALIFORNIA HEALTH CARE SYS · PI XIANG, YANG K · 2016 to 2021
–BLRD VA I01 BX002900NHLBI NIH HHS P01 HL141084NHLBI NIH HHS R01 HL127764NHLBI NIH HHS R01 HL133832NHLBI NIH HHS R01 HL147263NIA NIH HHS R01 AG055357NIGMS NIH HHS R01 GM129376NIMH NIH HHS R01 MH097887NIMH NIH HHS T32 MH112507NINDS NIH HHS R01 NS078792
Abstract
rationaleβ
objectiveTest localization and function of intracellular β METHODS AND
resultsMembrane fractionation, super-resolution imaging, proximity ligation, coimmunoprecipitation, and single-molecule pull-down demonstrated a pool of β
conclusionsFunctional β
Indexed as
Myocardial ContractionAdrenergic beta-AgonistsAdrenergic beta-AntagonistsAnimalsCalcium-Binding ProteinsCell MembraneCells, CulturedCyclic AMP-Dependent Protein KinasesFemaleHeart RateMaleMiceMice, Inbred C57BLMice, KnockoutMyocytes, CardiacOrganic Cation Transporter 3Adrb1 protein, mouseADRB2 protein, mouseAdrenergic beta-AgonistsAdrenergic beta-AntagonistsCalcium-Binding ProteinsCyclic AMP-Dependent Protein KinasesOrganic Cation Transporter 3Organic Cation Transport ProteinsPhospholambanReceptors, Adrenergic, beta-1Receptors, Adrenergic, beta-2catecholamineintracellular membranenorepinephrinephospholambanphosphorylation
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.