Evidence map›Paper›PMID 33185115›Full record

ReviewAmerican journal of physiology. Heart and circulatory physiology2021

Coronary remodeling and biomechanics: Are we going with the flow in 2020?

Patricia E McCallinhart, Benjamin W Scandling, Aaron J Trask

Open access · greenAbstract readReview
In one paragraph

Review in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Guidelines for the measurement of vascular function and structure in isolated arteries and veins.American journal of physiology. Heart and circulatory physiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Patricia E McCallinhartCenter for Cardiovascular Research, The Heart Center, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio.
Benjamin W ScandlingDepartment of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio.
Aaron J TraskCenter for Cardiovascular Research, The Heart Center, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio.
The Ohio State University · USNationwide Children's Hospital · US

Funding

Differential Macro- and Micro-Vascular Remodeling in Type 2 Diabetes and Metabolic SyndromeR00HL116769 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI TRASK, AARON J · 2016 to 2018
$747k
Novel Non-Invasive Coronary Flow Patterning to Predict Early Coronary Microvascular DiseaseR21EB026518 · NIBIB · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI TRASK, AARON J · 2018 to 2020
$684k
Asylum Research MFP-3D-BIO Atomic Force MicroscopeS10OD023438 · OD · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI TRASK, AARON J · 2017 to 2017
$316k
NHLBI NIH HHS R00 HL116769NIBIB NIH HHS R21 EB026518NIH HHS S10 OD023438ODCDC CDC HHS S10 OD023438
6 · The paper itself

Abstract

Under normal conditions, coronary blood flow (CBF) provides critical blood supply to the myocardium so that it can appropriately meet the metabolic demands of the body. Dogmatically, there exist several known regulators and modulators of CBF that include local metabolites and neurohormonal factors that can influence the function of the coronary circulation. In disease states such as diabetes and myocardial ischemia, these regulators are impaired or shifted such that CBF is reduced. Although functional considerations have been and continued to be well studied, more recent evidence builds upon established studies that collectively suggest that the relative roles of coronary structure, biomechanics, and the influence of cardiac biomechanics via extravascular compression may also play a significant role in dictating CBF. In this mini review, we discuss these regulators of CBF under normal and pathophysiological conditions and their potential influence on the control of CBF.

Indexed as

Coronary CirculationModels, CardiovascularVascular RemodelingAnimalsBiomechanical PhenomenaCoronary DiseaseCoronary VesselsHumansbiomechanicscoronary blood flowfunctionstiffnessstructure

Identifiers

PMID33185115
PMCPMC8082794
OpenAlexW3104788220

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.