SynthesisJournal of Alzheimer's disease : JAD2020
Alpha Power and Functional Connectivity in Cognitive Decline: A Systematic Review and Meta-Analysis.
Synthesis in Journal of Alzheimer's disease : JAD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Functional and effective EEG connectivity patterns in Alzheimer's disease and mild cognitive impairment: a systematic review.Frontiers in aging neuroscience · 2025Pooled it
- Randomized phase 2a trial assessing a novel septin molecular glue in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- A qEEG-based prognostic model for cognitive impairment after ischemic stroke: Development and internal validation.IBRO neuroscience reports · 2026Article
- Age-Related Changes in Spontaneous Brain Dynamics Revealed by Resting-State Magnetoencephalography.GeroScience · 2026Article
- Virtual brain and electroencephalography explain the variance of memory alterations in mild cognitive impairment.Alzheimer's research & therapy · 2026Article
- Source-space EEG alpha activity reveals brain age gaps due to neurodegeneration and disparity.Communications biology · 2026Article
- Electroencephalographic phenotypes of postoperative delirium in the perioperative period.Journal of anesthesia and translational medicine · 2026Review
- Can Music Therapy Improve Cognition in Dementia as Measured with Magnetoencephalography: A Hypothesis Study.Biomedicines · 2026Article
- Wearable EEG devices in the detection of mild cognitive impairment: a systematic review.NPJ digital medicine · 2026Article
- Resting state EEG mediates the association between physical activity and cognitive function in cognitively impaired elderly.Scientific reports · 2026Article
- Divergence of cortical neurophysiology across different neurodegenerative disorders compared to healthy ageing.Progress in neurobiology · 2026Article
- Microstates and connectivity states reveal task-related network reorganization in Alzheimer's disease patients.Clinical neurophysiology practice · 2026Article
- Exploring resting EEG correlates of age-related hearing difficulties.Frontiers in neuroscience · 2026Article
- Interpretable self-supervised transformers for resting-state EEG analysis in Alzheimer's disease.Frontiers in neuroinformatics · 2026Article
- The use of electroencephalography in neurodegenerative disease and its utility in dementia.NPJ dementia · 2026Review
- Quantitative electroencephalography as a next-generation tool in neurodiagnostics: significance, clinical applications, and practical interpretative frameworks.Frontiers in neuroscience · 2026Review
- Resting-State EEG Functional Connectivity and Independent Correlates of Cognitive Impairment in Patients with Atrial Fibrillation.Neuropsychiatric disease and treatment · 2026Article
- Brain power comparison between microgravity and head-down tilt bed rest: an electroencephalography approach.Scientific reports · 2025Article
- Targeting Executive Function and Language Impairments with tACS Combined with Behavioral Intervention in Primary Progressive Aphasia: A Case-Series, Pilot Investigation.Brain sciences · 2025Article
- EEG biomarkers for Alzheimer's disease: A novel automated pipeline for detecting and monitoring disease progression.Journal of Alzheimer's disease : JAD · 2025Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMild cognitive impairment (MCI) is a stage between expected age-related cognitive decline and dementia. Dementias have been associated with changes in neural oscillations across the frequency spectrum, including the alpha range. Alpha is the most prominent rhythm in human EEG and is best detected during awake resting state (RS). Though several studies measured alpha power and synchronization in MCI, findings have not yet been integrated.
objectiveTo consolidate findings on power and synchronization of alpha oscillations across stages of cognitive decline.
methodsWe included studies published until January 2020 that compared power or functional connectivity between 1) people with MCI and cognitively healthy older adults (OA) or people with a neurodegenerative dementia, and 2) people with progressive and stable MCI. Random-effects meta-analyses were performed when enough data was available.
resultsSixty-eight studies were included in the review. Global RS alpha power was lower in AD than in MCI (ES = -0.30; 95% CI = -0.51, -0.10; k = 6), and in MCI than in OA (ES = -1.49; 95% CI = -2.69, -0.29; k = 5). However, the latter meta-analysis should be interpreted cautiously due to high heterogeneity. The review showed lower RS alpha power in progressive than in stable MCI, and lower task-related alpha reactivity in MCI than in OA. People with MCI had both lower and higher functional connectivity than OA. Publications lacked consistency in MCI diagnosis and EEG measures.
conclusionResearch indicates that RS alpha power decreases with increasing impairment, and could-combined with measures from other frequency bands-become a biomarker of early cognitive decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.