Evidence map›Paper›PMID 33186716›Full record

ArticleNeuroImage2021

Age-related GABAergic differences in the primary sensorimotor cortex: A multimodal approach combining PET, MRS and TMS.

Koen Cuypers, Melina Hehl, June van Aalst, Sima Chalavi, Mark Mikkelsen, Koen Van Laere, Patrick Dupont, Dante Mantini, Stephan P Swinnen

Abstract read
In one paragraph

Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Koen CuypersDepartment of Movement Sciences, Movement Control & Neuroplasticity Research Group, Group Biomedical Sciences, KU Leuven, Heverlee, Belgium; REVAL Research Institute, Faculty of Rehabilitation Sciences, Hasselt University, Agoralaan Building A, 3590 Diepenbeek, Belgium. Electronic address: koen.cuypers@uhasselt.be.
Melina HehlDepartment of Movement Sciences, Movement Control & Neuroplasticity Research Group, Group Biomedical Sciences, KU Leuven, Heverlee, Belgium.
June van AalstNuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, and University Hospitals UZ Leuven, Leuven, Belgium.
Sima ChalaviDepartment of Movement Sciences, Movement Control & Neuroplasticity Research Group, Group Biomedical Sciences, KU Leuven, Heverlee, Belgium.
Mark MikkelsenRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Koen Van LaereNuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, and University Hospitals UZ Leuven, Leuven, Belgium.
Patrick DupontLaboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium; KU Leuven, Leuven Brain Institute (LBI), Leuven, Belgium.
Dante MantiniDepartment of Movement Sciences, Movement Control & Neuroplasticity Research Group, Group Biomedical Sciences, KU Leuven, Heverlee, Belgium; Brain Imaging and Neural Dynamics Research Group, IRCCS San Camillo Hospital, Venice, Italy.
Stephan P SwinnenDepartment of Movement Sciences, Movement Control & Neuroplasticity Research Group, Group Biomedical Sciences, KU Leuven, Heverlee, Belgium; KU Leuven, Leuven Brain Institute (LBI), Leuven, Belgium.

Funding

TR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2012 to 2020
$13.1M
Universal GABA-edited MRS at 3TR01EB016089 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Richard Anthony Edward Edden · 2013 to 2026
$5.4M
Simultaneous Hadamard Editing of GABA and GlutathioneR01EB023963 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2017 to 2024
$3.8M
NIBIB NIH HHS P41 EB015909NIBIB NIH HHS R01 EB016089NIBIB NIH HHS R01 EB023963
6 · The paper itself

Abstract

Healthy aging is associated with mechanistic changes in gamma-aminobutyric acid (GABA), the most abundant inhibitory neurotransmitter in the human brain. While previous work mainly focused on magnetic resonance spectroscopy (MRS)-based GABA+ levels and transcranial magnetic stimulation (TMS)-based GABA

Indexed as

AdultAgedAged, 80 and overAgingFemaleHumansMagnetic Resonance SpectroscopyMaleMultimodal ImagingPositron-Emission TomographyReceptors, GABA-ASensorimotor CortexTranscranial Magnetic StimulationYoung AdultReceptors, GABA-AAgingGABAMRSPETTMS

Identifiers

PMID33186716
PMCPMC7894275

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.