Evidence map›Paper›PMID 33188019›Full record

ArticleScience advances2020

Adaptive tuning of cell sensory diversity without changes in gene expression.

K Kamino, J M Keegstra, J Long, T Emonet, T S Shimizu

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 40 citations in OpenAlex.

  1. Growth-dependent sensory bet-hedging enhances collective navigation.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Nature physics · 2026
    Article
  5. Article
  6. ChemotaxingbioRxiv : the preprint server for biology · 2025
    Article
  7. ChemotaxingArXiv · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Optimal inference of molecular interaction dynamics in FRET microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Review
  14. Real-time detection of response regulator phosphorylation dynamics in live bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  15. The ecological roles of bacterial chemotaxis.Nature reviews. Microbiology · 2022
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Non-Genetic Diversity in Chemosensing and Chemotactic Behavior.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

K KaminoAMOLF Institute, Amsterdam, Netherlands.ORCID 0000-0003-1645-6398
J M KeegstraAMOLF Institute, Amsterdam, Netherlands.ORCID 0000-0002-8877-4881
J LongDepartments of Molecular, Cellular and Developmental Biology and Physics, Yale University, New Haven, CT, USA.ORCID 0000-0003-3754-9614
T EmonetDepartments of Molecular, Cellular and Developmental Biology and Physics, Yale University, New Haven, CT, USA. shimizu@amolf.nl thierry.emonet@yale.edu.ORCID 0000-0002-6746-6564
T S ShimizuAMOLF Institute, Amsterdam, Netherlands. shimizu@amolf.nl thierry.emonet@yale.edu.ORCID 0000-0003-0040-7380
Institute for Atomic and Molecular Physics · NLYale University · US

Funding

The contribution of phenotypic variability to chemotactic performanceR01GM106189 · NIGMS · YALE UNIVERSITY · PI EMONET, THIERRY · 2013 to 2022
$2.6M
Spontaneous Organization of Phenotypes during Collective MigrationR01GM138533 · NIGMS · YALE UNIVERSITY · PI EMONET, THIERRY · 2020 to 2023
$1.3M
NIGMS NIH HHS R01 GM106189NIGMS NIH HHS R01 GM138533
6 · The paper itself

Abstract

In the face of uncertainty, cell populations tend to diversify to enhance survival and growth. Previous studies established that cells can optimize such bet hedging upon environmental change by modulating gene expression to adapt both the average and diversity of phenotypes. Here, we demonstrate that cells can tune phenotypic diversity also using posttranslational modifications. In the chemotaxis network of

Indexed as

Escherichia coliEscherichia coli ProteinsAdaptation, PhysiologicalBacterial ProteinsChemotaxisGene ExpressionBacterial ProteinsEscherichia coli Proteins

Identifiers

PMID33188019
PMCPMC7673753
OpenAlexW3105581070

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.