ArticleEuropean heart journal. Cardiovascular Imaging2021
Quantitative cardiovascular magnetic resonance myocardial perfusion mapping to assess hyperaemic response to adenosine stress.
Article in European heart journal. Cardiovascular Imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Diagnostic and Prognostic Value of Stress Cardiovascular Magnetic Resonance Imaging in Patients With Known or Suspected Coronary Artery Disease: A Systematic Review and Meta-analysis.JAMA cardiology · 2023Pooled it
- Advances in Myocardial Perfusion MR Imaging: Physiological Implications, the Importance of Quantitative Analysis, and Impact on Patient Care in Coronary Artery Disease.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022Pooled it
- Reduced regadenoson dose using heart rate-targeted titration in paediatric stress perfusion CMR.European heart journal. Imaging methods and practice · 2026Article
- Hyperaemic effects of adenosine and dobutamine in heart failure with reduced ejection fraction: a quantitative perfusion CMR study.European heart journal. Imaging methods and practice · 2026Article
- Value of cardiovascular magnetic resonance-derived quantitative myocardial blood flow assessment in the setting of chronic coronary occlusion.European heart journal. Cardiovascular Imaging · 2025Article
- Quantitative perfusion by cardiac magnetic resonance imaging reveals compromised myocardial perfusion in patients with angina with non-obstructive coronary artery disease.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Systematic underestimation of myocardial perfusion reserve by regadenoson stress perfusion CMR-when haste makes waste.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Article
- Haemodynamic and hyperaemic effects of adenosine in patients with atrial fibrillation undergoing quantitative myocardial perfusion cardiovascular magnetic resonance.European heart journal. Imaging methods and practice · 2024Article
- High-resolution free-breathing automated quantitative myocardial perfusion by cardiovascular magnetic resonance for the detection of functionally significant coronary artery disease.European heart journal. Cardiovascular Imaging · 2024Article
- The Role of Multimodality Imaging (CT & MR) as a Guide to the Management of Chronic Coronary Syndromes.Journal of clinical medicine · 2024Review
- Differences in quantitative myocardial perfusion mapping by CMR at 1.5 T and 3 T.American heart journal plus : cardiology research and practice · 2024Article
- Coronary microvascular function and visceral adiposity in patients with normal body weight and type 2 diabetes.Obesity (Silver Spring, Md.) · 2022Article
- Changing Paradigms in the Diagnosis of Ischemic Heart Disease by Multimodality Imaging.Journal of clinical medicine · 2022Review
- Stress CMR in Known or Suspected CAD: Diagnostic and Prognostic Role.BioMed research international · 2021Review
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16 authors at 5 institutions in 2 countries.
Funding
Abstract
aimsAssessment of hyperaemia during adenosine stress cardiovascular magnetic resonance (CMR) remains a clinical challenge with lack of a gold-standard non-invasive clinical marker to confirm hyperaemic response. This study aimed to validate maximum stress myocardial blood flow (SMBF) measured using quantitative perfusion mapping for assessment of hyperaemic response and compare this to current clinical markers of adenosine stress. METHODS AND
resultsTwo hundred and eighteen subjects underwent adenosine stress CMR. A derivation cohort (22 volunteers) was used to identify a SMBF threshold value for hyperaemia. This was tested in a validation cohort (37 patients with suspected coronary artery disease) who underwent invasive coronary physiology assessment on the same day as CMR. A clinical cohort (159 patients) was used to compare SMBF to other physiological markers of hyperaemia [splenic switch-off (SSO), heart rate response (HRR), and blood pressure (BP) fall]. A minimum SMBF threshold of 1.43 mL/g/min was derived from volunteer scans. All patients in the coronary physiology cohort demonstrated regional maximum SMBF (SMBFmax) >1.43 mL/g/min and invasive evidence of hyperaemia. Of the clinical cohort, 93% had hyperaemia defined by perfusion mapping compared to 71% using SSO and 81% using HRR. There was no difference in SMBFmax in those with or without SSO (2.58 ± 0.89 vs. 2.54 ± 1.04 mL/g/min, P = 0.84) but those with HRR had significantly higher SMBFmax (2.66 1.86 mL/g/min, P < 0.001). HRR >15 bpm was superior to SSO in predicting adequate increase in SMBF (AUC 0.87 vs. 0.62, P < 0.001).
conclusionAdenosine-induced increase in myocardial blood flow is accurate for confirmation of hyperaemia during stress CMR studies and is superior to traditional, clinically used markers of adequate stress such as SSO and BP response.
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