Trial reportEuropean journal of clinical pharmacology1987
Kinetics of human and porcine insulins in normal and type I diabetic subjects.
Trial report in European journal of clinical pharmacology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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0 citing papers in PubMed, 3 citations in OpenAlex.
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3 authors at 1 institution in 1 country.
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Abstract
Human and porcine insulin were infused intravenously at various rates into 4 normal and 6 Type I diabetic subjects, using a double-blind cross-over design and a euglycaemic glucose clamp, to study the relationship between the steady state plasma free insulin concentration and its plasma disappearance rate. By mathematical model validation procedures both human and porcine insulin were found to obey saturation kinetics in normal subjects and first order kinetics in diabetic subjects in the insulin concentration range studied (0-2 nmol/l). No differences in parameters were observed between the two types of insulin in the study groups. The median clearance rate of insulin in normal subjects was 31 ml.kg-1.min-1 at infinitesinal plasma insulin concentrations versus 21 ml.kg-1.min-1 in the diabetic subjects. Thus, at physiological plasma concentrations both human and porcine insulin disappear faster via the saturable mechanism(s) found in normal subjects than via the apparently linear mechanism(s) found in diabetic subjects.
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